dr in trouble
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In the case of chronic pressure overload as occurs with chronic hypertension or aortic stenosis- the ventricular chamber radius may not change; however, the wall thickness greatly increases as new sarcomeres are added in-parallel to existing sarcomeres. This is termed concentric hypertrophy. This type of ventricle is capable of generating greater forces and higher pressures, while the increased wall thickness maintains normal wall stress. This type of ventricle becomes "stiff" (i.e., compliance is reduced), which can impair filling and lead to diastolic dysfunction.
Sometimes the chamber radius is increased and the wall thickness is increased moderately - this is termed eccentric hypertrophy - and can occur when there is both volume and pressure overload. An example of this would be when systolic dysfunction and a volume overload state occur in a concentrically hypertrophied heart, thus stimulating chronic chamber dilation. Chamber dilation occurs as new sarcomeres are added in-series to existing sarcomeres.
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| Drtweetie
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thanks for the review, dr in trouble!
Wasn't sure about chamber radius and wall thickness, but you cleared things up.
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| DrVirgo
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Nice explanation...
I also came across this:
Concentric Hypertrophy is seen in Aortic stenosis. Eccentric in Valvular regurgitation. (from UW HY Notes).
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