asmi
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can anybody tell me what is "plaque" made up of ?
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| TONY PAUL
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When the endothelium is damaged, various materials begin to accumulate on the inner wall of the artery, forming plaque. These materials are:----------------------------
Fats
Cholesterol
Fibrin (a blood clotting factor)
Platelets (a type of blood cell involved in clotting)
Cell Debris
Calcium
Deposits of plaque trigger accumulation and division of additional cells in the endothelium of the artery. And these cells coz further atherosclerotic damage.
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| galleta
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A good description I got from Pathophysiology for the B&W:
Plaque consistis of 1) A core of lipids, necrotic debris, macrophages(foam cells), lymphocytes 2)Core covered by fibrous cap made of smooth muscle cells & collagen 3) Rupture of debris through cap exposes subendothelial layer of vessels to coagulation cascade, allowing acute thrombus to occur in already narrowed vessel
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| asmi
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thanks
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| Bela
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Hey guys,
I was just gonna post the same question. I looked into the Path BRS and also in Goljan's notes but the components of the cap and the core are different. I mean, where is the Calcium found? How about the foam cells? Because BRS has the foam cells in both places.
Hmm, can someone clarify it?
Also, what is the pathopneumonic for atherosclerosis? It's the fibrous plaque, right? Not the fatty streak....cuz I think even babies have fatty streaks.
Thnx
___________________
La vita e bella!
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| galleta
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I looked it up in Robbin's Pathologic Basis of Disease and it seems like the plaque summary I put up from "Pathophysiology for the B&W" is just a simplified overview of plaques. Robbin's states that the components of the plaque varies in different plaques, depended on stage and severity.
From a diagram of a plaque in the textbook (pg 500, 6th ed.) it shows that the fibrous cap of a well developed plaque can be made up of smooth muscle cells, macrophages, foam cells, lymphocytes, collagen, elastin, proteoglycans and neovascularization. The necrotic center has cellular debris, lipids (mostly cholesterol crystals), foam cells , and calcium. Calcification indicates advanced disease.
Fatty streaks are considered precursors to fibrous plaques.
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