asmi
Forum Hero
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Why does the pt develops gynecomastia ,testicular atrophy in alcoholic cirrhosis ?
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| step1taker
Forum Senior
Topics: 2
Posts: 105
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because liver is responsible for the metabolism/conjugation of estradiol ( a lipid soluble substance) to make it water soluble for excretion.Hence, if there is hepatic cirrhosis (damaged liver), estrogen is not excreted, builds up causing gyncomastia, increase cappillary fragility-caput medusae, etc.
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| asmi
Forum Hero
Topics: 1043
Posts: 4,609
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agree....
:arrow: decreased testicular testesterone production ....explains testicular atrophy.
:arrow: decreased hepatic extraction of androstenedione .
:arrow: increased aromatase activity...converts testesterone to estrogens (peripheral adipose tissue)
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