GOGETA
I'm Dr. GOGETA
Topics: 321
Posts: 2,710
|
hey I remember that PNH=paroxistical nocturnal hemolytic anemia is caused by a problem in a receptor that the RBC dont have so they are expose to be attack, now thats from UW, but conrad and goljan says that is because we get acid during night.
Can someone explain the phyiopathology of this.
thanks
___________________
As a general rule, the better it felt when you said it, the more trouble it's going to get you into.
|
| kashdoc21
Forum Senior
Topics: 52
Posts: 127
|
PNH = it is due to lack of DAF in the RBC memb which protects them from the acidic env
so essentially it a memb defect in RBC leading to haemolytic anemia
|
| cirus
Forum Guru
Topics: 108
Posts: 740
|
in PNH, there is phosphatadyl indol glycan 1 (PIG1) defic, leading to memb defect..This is d t stem cell abnormality.
complement will stick to the RBCs leading to increased vulnerability to rupture esp at night d t CO2 retntion, & ofcourse folate def helps (larger cells)
DAF(decay accelerating factor is an invesstig for diag, not a factr defic)
mort d t Budd Chiari synd (thromboembolism)
hope that helps
|
| GOGETA
I'm Dr. GOGETA
Topics: 321
Posts: 2,710
|
Thanks guys for the reply, t5hats what I remember
___________________
As a general rule, the better it felt when you said it, the more trouble it's going to get you into.
|
|
| |
| | | | |
