drtanvir
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HY Notes: CK(Q-bank)
• Familial short stature: normal birth weight and length Î age of 2-3 years growth decelerate and drops to 5th percentile Î The onset and progression of puberty normal : Bone age is typically consistent with the chronologic age.
• Immunizations:
Hep B vaccine- At birth, 1 month, and 6 months
DTaP- At 2, 4, and 6 months, 15-18 months, and 4-6 years Td booster- 11-12 years, and then every 10 years Hib- At 2, 4, and 6 months, and 12-15 months
IPV- At 2 and 4 months, 6-18 months, and 4-6 years
MMR- At 12-15 months and 4-6 years
Varicella- 12 months
• Chemo-prophylaxis tuberculosis: The usual agent isoniazid. Indicated in the following groups:
1) tuberculin skin test has converted from negative to positive within the previous 2 years;
2) all small children (<4 years of age)exposed by known close contact to a person with untreated tuberculosis or who have a positive PPD; In young children, not to delay chemoprophylaxis until the PPD test becomes positive in child,
3) all HIV patients with positive PPD;
4) elderly patients with a definite conversion of PPD;
5) PPD positive persons with apical scars;
6) PPD positive persons with significant risk of recurrence due to diabetes mellitus, prolonged corticosteroid therapy, gastrectomy, end-stage renal disease, or gastric stapling.
• CHARGE syndrome: colobomas, heart defects, choanal atresia, retardation, genitourinary abnormalities/ cryptorchidism and ear anomalies,not genetically transmitted and is not associated with a teratogenic effect of any substance.
• Amount of Factor VIII to hemophiliac A patients: weight in pounds x 20 x desired plasma level in units. (Not applicable in hemophiliac B patients because Factor IX tends to bind to the endothelium of the vessel walls.Monitor the patient for cessation of bleeding or check clotting times before assuming that a calculated dose of Factor IX had its intended effect)
• Ataxia-telangiectasia: autosomal recessive disease.Ataxia,Choreoathetoid movements, slurred speech, ophthalmoplegia, and progressive mental retardation,Telangiectasias.Recurrent sinopulmonary infections. lack of IgA and IgE, cutaneous anergy and a progressive cellular immune defect. predisposition for certain cancers (leukemias, brain cancer, and gastric cancer). Most of these patients die of their neurologic deterioration by age 30.
• Irreversible muscle weakness in Duchenne muscular dystrophy seen after ventilator put for respiratory distress due to pneumonia etc Îhypoventilation on weaning Îtracheostomy will reduce the dead space and airway resistance.
• Infants usually double their birth weight by 6 months
Infants are triple their birth weight by the age of 12 months.
Infants usually quadruple their birth weight by 24 months.
Infants usually double their length by 4 years.
• Most patients with ALL are significantly granulocytopenic = like aplastic anemia associated with bone pain & fever = features like ecchymoses & infections
• Orthostatic proteinuria:very common Îprotein excretion rate is higher while the child is in an upright position Îobtain a "first morning" urine before the child has had much time in an upright position. DDx Minimal change ds = Edema, hypercholesterolemia & hypoproteinemia
• Neonate with pneumonia and h/o conjunctivitis on the fourth day of life. The leukocyte count is elevated at 15,000 with 40% eosinophils = suspect Chlamydia
• Corrossive ingestion: ingestion can cause severe esophageal necrosis of the liquefaction type. Full-thickness injury is common. In severe cases, it can cause esophageal perforation and mediastinitis. Acid ingestion causes coagulation necrosis and eschar formation. The eschar tends to protect the esophagus from full-thickness injury and corrosive perforation.
Perform an esophagoscopy within 24 hours of exposure for the following patients following alkali ingestion:
1. Small children
2. Symptomatic older children and adults
3. Patients with abnormal mental status
Esophagoscopy should not be performed in patients with evidence of gastrointestinal perforation, significant airway edema, or necrosis and in those who are hemodynamically unstable.
• Children with sickle cell disease are at risk of serious bacterial infection and sepsis because they have impaired splenic function. Intravenous ceftriaxone is the most commonly used antibiotic in a febrile child with sickle cell disease. It is effective against both S. pneumoniae and H. influenzae.
• Red urine = hematuria, hemoglobinuria, myoglobinuria, certain foods or medications (e.g., rifampin, nitrofurantoin, chloroquine, azo dyes, beets, and blackberries), and the presence of urates.
+ Strip-test for blood in a urinalysis = red blood cells, hemoglobin or myoglobin = perform microscopic analysis to DDx
Raised serum creatinine phosphokinase = rhabdomyolysis = admit for aggressive IV hydration and treatment with sodium bicarbonate to alkalinize the urine to prevent precipitation of the myoglobin in the renal tubules.
• Nightmares:frightening dreams that awaken the child from REM sleep recall details of the dream. Nightterror: Stage 3 or 4 sleep,not recalled Rx simply let it go but prevent injury
• Functional abdominal pain is pain that lasts for more than 3 months and often interferes with normal activity. The pain is periumbilical and often hard to describe. The pain typically does not awaken patients from sleep or interfere with pleasant activities. The pain is real and is the result of the regulation of gastrointestinal motility in response to either psychological or physical stress.
• Fragile X male = Adv Cytogenetic testing in female siblings = Heterozygous females frequently have developmental and behavioral problems such as ADHD. They may also have borderline or mild mental retardation.
• Rx Acne vulgaris: retinoid (tretinoin, adapalene, and the new yeast-derived agent azaleic acid).S/E skin irritation & photosensitivity. Frequent face washing with strong soap will probably cause exacerbation of acne. Gentle face washing once or twice daily with mild soaps is recommended.
• Toxicities tricyclic antidepressant ingestion:
1. A prolongation of the QRS interval is highly predictive of both cardiac and CNS toxicities
2. Right deviation of the QRS axis (greater than 120 degrees) is very predictive of cardiac toxicity from tricyclics.
• Fat embolism brain = multimodal petechiae in the white matter represent the most common pathologic change.
Corpus callosum and cerebral peduncles small petechiae = Diffuse axonal injury = coma a few hours to days after head trauma.
Multiple cortical infarcts, usually of the hemorrhagic type = Septic embolism / white matter is spared.
• Prostatic abscess:Infecting organisms include aerobic gram-negative bacilli and Staphylococcus aureus.
• Hyper IgM immunodeficiency = increased susceptibility to major gram-positive pathogens and opportunistic infections (such as the patient's Pneumocystis infection). The biochemical basis defect in a receptor on the T cell membrane that helps to trigger B cell switching from IgM to IgA, IgG, and IgE.
• The tidal volume for a patient on respirator is generally estimated as 10 mL/kg of weight.
• Screening every 5 years, a random cholesterol level should be checked = > 240 mg/dL =fasting lipid profile
• Scaling skin on back and extensor surfaces of the extremities/flexor surfaces are uninvolved. Cracking of the skin is prominent on the palms and soles. + atopy = ichthyosis vulgaris, Rx minimizing bathing with use of soaps only in the intertriginous areas. Bathing limited to 10-minute periods (to hydrate the stratum corneum), followed by immediate application of an emollient such as petrolatum, can help to control the scaling. In addition, 50% propylene glycol in water under occlusion by thin plastic film or bags during the night is helpful in adults, but is not usually used in children.
• Nummular dermatitis: chronic inflammation / etiology unknown. Coin-shaped/discoid itchy patches of vesicles and papules (ooze serum and crust over)numerous on the extensor surfaces of the extremities and on the buttocks. Heal and then reappear at the same sites. Microscopically, localized spongiosis (corresponding to edema) of the epidermis, which may also contain minute fluid-filled holes that correspond to the tiny
vesicles seen clinically in early lesions. Treatment of these patients is problematic, and numerous regimens involving corticosteroids or antibiotics have been recommended, each of which appears to work with some but not all patients.
• Euthyroid sick syndrome: seriously ill patient with low T4 /T3, but below normal, normal, or minimally elevated TSH and clinically do not have clinical hypothyroidism.DDx true hypothyroidism (significantly raised TSH).
• End-stage liver disease/Cirrhosis Î renal vasoconstriction occurs worsening fatigue and confusion Î distal convoluted tubule responds by conserving sodium Î diminished urine output and low urinary sodium Î Deranged BUN/creatinine Î hepatorenal syndrome Î Rx Liver transplantation Î reverse this vasoconstriction and kidney function will return to normal.
• HIV encephalitis (AIDS dementia complex): most common CNS complication in AIDS = cognitive impairment, incontinence, impairment of motor skills, and confusion = sub acute inflammatory infiltration of the brain caused by direct spread of HIV = diagnosis of exclusion = MRI studies and CSF analysis are useful in excluding other CNS diseases.
• Patient with respiratory distress due to pneumonia Î oxygen saturation is 80% on room air ÎHypoxia puts at significant risk for delirium, cardiac arrhythmias, and cardiopulmonary arrest Î Oxygen should first be administered noninvasively Îstarting with a non-rebreather face mask ÎFailed Î go for invasive methods like endotracheal intubation.
• Hospitalization in community-acquired pneumonia :Criteria for hospitalization: one of the following is needed:
1. respiratory rate > 30 breaths/min,
2. room air PaO2< 60 mm Hg,
3. O2 saturation less than 90% on room air,
4. or bilateral or multiple lobes involved
• The normal value for the anion gap is 12 ± 4 mEq/L
• Gaucher disease: deficiency of the enzyme glucocerebrosidase (Ashkenazi Jews ) Îprogressive accumulation of glucocerebroside within lysosomes of histiocytes Î Gaucher cells, large histiocytes with their cytoplasm engorged with glycolipid = "crumpled tissue paper" appearance Îmost common adult variant (type I) =most severely affected organs are the bone marrow, liver, and spleen Î Bone marrow involvement =progressive pancytopenia and bone fractures Î Glucocerebrosidase levels in circulating leukocytes: diagnostic. In the US, the disease is Rx glucocerebrosidase named alglucerase(safe but expensive)
• an erythematous, slightly raised, 2-cm patch of skin on sun
exposed area (Face mostly) Î area has a rough, very adherent, yellow-brown scale Î Actinic keratosis
ÎRx application of 5-fluorouracil cream twice daily x 4 one-week cycles alternated with no treatment weeks Îheal without scarring.
• Ventilator delivering high concentrations of oxygen Î lead to irreversible pulmonary fibrosis ÎUse positive-end expiratory pressure (PEEP) to prevent the development of oxygen toxicity ÎBut PEEP does increase the risk of both barotrauma and hypotension by impairing right-sided heart filling.
• Secondary hyperparathyroidism developed in renal failure in an attempt to correct the hypocalcaemia bone calcium deficits and pathologic bone lesions ÎRx Calcium supplementation in Renal failure
• Atypical nevus(Dysplastic):size from 5 to 12 mm Îmost commonly on sun-exposed skin Îround in color, but some have subtly notched borders or are slightly asymmetrical Î intermediate category between obviously benign nevi and malignant melanoma Îincreased rate of progression to melanomaÎ Isolated dysplastic nevi are often excised to remove the melanoma riskÎcases with large numbers Î careful monitoring with serial photographs can identify any changing lesions which may be undergoing malignant transformation.
• Post-MI patients: Ejection fraction near or minimally subnormal Rx Beta blockers Îdecreasing both oxygen demand and the incidence of ventricular arrhythmia Î Improved survival
But if ejection fractions less than 40% Î Rx Angiotensin-converting enzyme (ACE) inhibitors
• Tension headache: headache often triggered or worsened by stressful situations, anxiety and fatigue Rx NSAIDs
• Eosinophilic fasciitis:Orange peel skin on the anterior aspects of the extremities= scleroderma-like disorder involving the arms, legs, and sometimes face and trunk, but not usually the hands and feet Î lead to eventual restriction of arm and leg motion related to inflammation and fibrosis of fascia ÎBiopsy of the skin or fascia shows cellular infiltrates with histiocytes, plasma cells, lymphocytes and (in only some cases, despite the name) eosinophils Î Rx high dose prednisone followed by tapering and maintenance for 2 to 5 years on low dose prednisone.
• Pulsus paradoxus: significant fall in systolic blood pressure with inspiration = severe asthmatic attack Look for associated accessory muscles of respiration, i.e., the internal intercostal muscles and the sternocleidomastoid muscles.
• Traumatic hemolytic anemias: repeatedly compressed tiny blood vessels, causing fragmentation of some red cells (triangle and helmet shapes)Î e.g. forced march DDx rhabdomyolysis: high creatine kinase
• Atrial fibrillation (in CHF) Îcauses cardiovascular embarrassment and pulmonary edema Îadequate management of atrial fibrillation is rate control Î Rx Digoxin with or without a nodal agent such as a beta blocker.However,in sinus tachycardia seen with hyperthyroidism DOC is propanolol alone.
• Bleeding in diverticular Î usually due to the disruption of an often single arteriole or small artery in a diverticulum Îvessel can be sufficiently stretched by the diverticulum that it cannot undergo contraction.
• Sheehan syndrome: panhypopituitarism due to intrapartum necrosis of the pituitary Îinsulin challenge ÎMeasuring plasma levels of growth hormone and cortisol and evaluating thyroid hormones and TSH levels ÎRx hydrocortisone (IV not oral like prednisolone) and thyroid hormones.
• Blood supply from 1978 to 1985 was likely to be tainted with HIV positive blood Îpatients with a history of blood transfusions during these years even if currently asymptomatic, should be screened.
• Hyperkalemia ÎFirst to give: IV calcium gluconate Î to counteract the effect of the high potassium on the heart and muscle
• Hypercalcemia Î Rx IV saline and furosemide Îrapid and safe way to lower serum.
• hemochromatosis = total body iron load >5 g; (hemosiderosis = milder iron overload)
• cirrhosis and portal hypertension Î Rx Propanolol (to reduce his portal pressure) and Frusemide to relieve ascites Î dehydration (dry mucous membranes) related to his diuretic Î BUN elevated Îmay exacerbate hepatic encephalopathyÎ but pulse does not demonstrate a reflex tachycardia because of the propranolol.
• In portal hypertension strictly restrict or entirely avoid any medications with a sedative effect, e.g., benzodiazepines as they may ppt an encephalopathy.
• Silent lymphocytic thyroiditis: common disorder of postpartum women,autoimmune reaction to the thyroid gland Îproduce transient hyperthyroidism (related to follicle destruction) followed by hypothyroidism (that may be either permanent or resolve within 1 year).
• Seborrhic Keratosis: This lesion is characterized by light brown to black papules or plaques with an adherent waxy, greasy scale. The "stuck-on" appearance is very characteristic. It is most often found on the face and trunk.
• The findings of a coagulopathy or of an encephalopathy confer the worst prognosis in patients with acute viral hepatitis.These findings, in fact; suggest the possibility of fulminant hepatic failure.
• IgA type heavy chain diseas:centered in the Middle East ,ages of 10-30Îpresent with abdominal mass and malabsorption (behaves like an abdominal lymphoma but not mailgnant)Îconfined to the gut and mesenteric lymph nodes Îmay represent an aberrant reaction to some sort of bacterial infection Î Rx corticosteroids, cytotoxic drugs and broad-spectrum antibiotics.
• Pemphigus vulgaris:uncommon autoimmune skin disorder characterized by blistering and erosions involving the mucous membranes and skin
Î autoimmune attack is on the junctions between epithelial cells in the epidermis blisters Î occur high in
Îthe epithelium and can rupture easily(Nikolsky's sign) Î begin in the mouth rapid Î rupture of the blisters may lead to the impression that the initial lesion is an ulcer rather than a blister Î IgG deposition on
epithelial cell surfaces Îlife-threatening as a result of fluid/electrolyte imbalance, secondary infection, or
complications of the high-dose corticosteroid therapy.
• Marrow fibrosis suggests myelofibrosis. The marrow in aplastic anemia is fatty, rather than fibrotic
• Excess vitamin C supplementation can lead to uricosuria and the development of calcium oxalate stones.
• The perfusion territory of the anterior spinal artery includes the anterior horn cells and part of the pain and temperature pathways. Thrombosis of this artery causes flaccid paralysis, loss of bowel and bladder function and loss of pain and temperature sensation
• Infectious Mononucleosis: Ampicillin therapy leads to a maculopapular rash. An antibiotic should not be given.
• To rapidly assess for the possibility of antifreeze ingestion, the physician can evaluate the patient's urine under a Wood's lamp for fluorescence. Manufacturers of ethylene glycol-containing antifreezes typically add fluorescein to the mix, which will fluoresce under a Wood's lamp.
• Paroxysmal nocturnal hemoglobinuria(Marchiafava-Micheli syndrome):genetic defect in glycosylphosphatidyl-inositol "anchor Î marked sensitivity of RBC to serum complement factor C3 Î Hemolysis triggered by infection, iron use (prescribed to treat the anemia), vaccination, or menstruation Îpredisposed for thrombotic disease, including Budd-Chiari Syndrome ÎHam test: classic but non-specific:acid incubation causes red cell lysisÎflow cytometric analysis using CD 55 and CD 59 (most definitive) .Prognosis good only a few require allogenic bone marrow transplant.
• AMI : Thrombolytic therapy is indicated in patients up to 75 years of age .Absolute contraindications include a bleeding diathesis, major surgery or trauma within 6 months, gastrointestinal bleeding, or the presence of aortic dissection or a known intracranial tumor.
• Whenever you see ‘Lewy’s Body’ think of relation with Parkinson’sÎ dementia with visual hallucinations and extrapyramidal signs Îdementia with Lewy bodies Î Like parkinsons it shows fluctuating clinical course with alternating periods of improvement and deterioration ÎDDx Pick dementia =Personality changes & disinhibition,affecting younger than 65 Îstriking atrophy of the frontal and anterior temporal lobes.
• Suspected lung carcinoma ÎhoarsenessÎmetastatic disease to the recurrent laryngeal nerveÎincurability by surgical means.
• Charcoal is DOC within 4 hrs of toxic ingestion in any case Î also applicable to Acetominophen ÎGive charcoal + N-acetylcysteine within 4hrs of ingestion ÎIf >4 hrs but <10 hrs = N-acetylcysteine alone Î continue oral treatment for 72 hours.
• Tangier disease:alpha-lipoprotein deficiency Îvery low high-density lipoprotein (HDL)Îrecurrent polyneuropathy, lymphadenopathy, and hepatosplenomegaly due to storage of cholesterol esters in
reticuloendothelial cells Îorange-yellow tonsillar hyperplasia (due to the cholesterol ester deposits) is a distinctive clue
• HIV patient with bloody diarrhea + tensmus + urgency/fecal incontinence Î Sigmoidoscopy showing proctosigmoiditis with deep ulcers Î suspect CMV
• Obese patient? in postop state Î developing respiratory distress Î think about PE
• Nephritic syndrome with bland urine in drug users who "skin pop" their drugs and have recurrent infections Î Enlarged kidneys Î ?Amyloidosis DDx Heroin Nephritis=Small kidneys
• Idiopathic hypertrophic subaortic stenosis (Earlier name of Hypertrphic cardiomyopathy):frequent cause of syncope or near syncope in young patients Îcharacteristic murmur by its increase with the Valsalva maneuver (Any maneuver that decreases left ventricular size will increase the murmur because the obstructive component increases as the left ventricular cavity shrinks Î systolic ejection murmur is diminished when the patient lies down (This increases cardiac size by increasing venous return and tends to diminish the intensity of the murmur. This increases the ventricular size and diminishes the murmur).Rx Beta-blockers, such as propanolol, help relax the left ventricular smooth muscle and reduce ventricular outflow obstruction.
• Mesalamine (active ingredient 5-aminosalicylic acid) rectal suspension, suppositories, delayed release oral tablets and controlled release oral capsules Înot absorbed and acts topically Î modulation of arachidonic acid metabolites, including prostaglandins, leukotrienes, and hydroxyeicosatetraenoic acids Îwell tolerated except sulfite sensitivity.
• Hypertensive emergency (Raised both systolic & diastolic BP)may lead to increased Intracranial tension(Blurry vision/Papilledema) subarachnoid hemorrhage and end-organ failure (Like renal manifesting as ‘cola’ colored urine) ÎRx Control BP but the blood pressure should not be lowered too far Î systolic pressure in the range of 160-170 mm Hg because some of the elevated pressure may represent a compensatory mechanism to maintain cerebral perfusion pressure in the face of increased intracranial pressure or cerebral arterial narrowing (May lead to watershed infarcts)ÎIV nitroprusside is a good agent because it can be titrated with the blood pressure. If the pressure drops too low, the IV can be turned off.
• IgG subclass deficiency: minor forms of immunodeficiency disease Îdeficiency may involve either or both IgG2 and IgG3 with or without IgG4 deficiency Î (IgG1 is the major form, and its deficiency leads to a deficiency of total IgG (by definition not considered a "subclass" deficiency) Îpotentially clinically important point that patients with IgG2 deficiency may also have IgA deficiency and may develop anaphylaxis if given IgA-containing blood products.
• Chronic "autoimmune" hepatitis Î young age & hypergammaglobulinemiaÎbiopsy demonstrating portal inflammation with lobular damage resulting in bridging necrosis
1. Type I(classic type: most frequent):associated with antinuclear and anti-smooth muscle autoantibodies
2. Type II(more common in women of Western European descent):associated with autoantibodies to circulating liver-kidney microsomes. insidious + amenorrhea.
• Chronic hepatitis C Î positive enzyme immunoassay test for HCV-antibodies(this test may be falsely positive in situations with hypergammaglobulinemia like seen in chronic autoimmune hepatitis) Îpositivity should be confirmed by a more specific RIBA.
• Ganglion cyst: degenerative nontumourous/cystic swellings with gelatinous material having high hyaluronic acid content the center over dorsal aspect of the wrists, usually near or attached to tendon sheaths and joint capsulesÎ Common sites:65%scapholunate joint,volar aspect of the radius and the flexor tendon sheath.
Îregress spontaneously or after needle aspiration of the contents. Recurrent ganglia or ganglia that are cosmetically unacceptable to the patient can be surgically excised, but may recur after excision.
• Strenuous exercise like swimmingÎdevelopment of headache, dizziness, One sided arm clumsiness and leg weakness + loss of pain and temperature sensation on same side face and contra lateral body areas No Î prior illness Î ? lateral medullary syndrome Îinvestigate vertebral artery dissection.
• Diagnosis of Myocardial infarction requires either characteristic ST segment elevations on the ECG OR elevations in serum markers for cardiac injury. ‘Myocardial ischemia’ may or may not always manifest as MI(ÎAngina). Diabetics often have silent ischemia.
• Propranolol is considered to be relatively contraindicated in patients with peripheral claudication & asthma.
• HIV/ lymphomas/organ transplants. ÎEvidence of destruction of myelin at multiple sites in the CNS ÎPMLÎJC virus(papovavirus)Î involves Oligodendrocytes in active lesions contain characteristic intranuclear inclusions.
• In constrictive pericarditis (calcification of the anterior pericardium) a pericardial knock is heard 0. 06-0. 12 seconds after the aortic valve closes. This corresponds to the sudden cessation of ventricular filling.
• Hypertrophic heart disease is the best recognized cause of diastolic dysfunction
• ECG PÎ waves preceding the QRS complex but no two P waves have the same morphology Î ‘Multifocal atrial tachycardia’ÎVariable P wave morphology and PR and RR intervals Î associated with severe pulmonary diseaseÎcontrol of this tachycardia comes with improved ventilation and oxygenation.
• HSV is thought to cause encephalitis following transport to the brain along the trigeminal nerve.
• HIV with pneumocystis showing respiratory distress oxygen saturation on room air is 71% ÎRx intravenous trimethoprim-sulfamethoxazole and prednisone Îgiven in any patient showing significant respiratory distress or room air oxygen saturation of less than 75 % Îotherwise in HIV Steroids are only given if the question of adrenal insufficiency, a common complication of HIV, is suspected.
• HIV patient with watery diarrhea Îtypical small bowel-type diarrhea(weakness & weight loss)Îmost common etiology cryptosporidiosisÎspores can be seen on the tips of the villi on biopsy.
• Hypotension always accompanied with Tachycardia but when it is associated with Bradycardia ÎIt is vagal response ÎRx Atropine.E.g: post AMI
• Amyotrophic lateral sclerosis is a progressive motor neuron disease that affects both upper and lower motor neurons. Patients present with a gradual onset of asymmetric weakness of the distal limb. Even in advanced disease, sensory and bladder function are preserved. On exam, there is hyperactivity of muscle stretch reflexes.
• If autonomic dysfunction is suspected in a diabetic patient, a useful maneuver on physical examination is to look for a decrease in heart rate in response to the Valsalva maneuver (forced expiratory effort against a closed airway).
• Meniere disease = tinnitus, vertigo, and progressive hearing lossÎ thought to be related to a degeneration of the vestibular and cochlear hair cells ÎRx includes bed rest, a low-salt diet, dimenhydrinate, cyclizine or meclizine.
• Heparin-induced thrombocytopenia (HIT) is the result of platelet aggregation (platelet count falls below 50,000/mm3) caused by heparin-induced antibodiesÎlead to limb-threatening thromboses and constitutes a medical emergency (Arterial thrombosis is a manifestation of the HIT syndrome)Î Rx discontinue heparin and use lepirudin.
• An atypical gastric upset, heartburn, indigestion may turn out to be a myocardial ischemia ++> Look for objective signs of sympathetic activation including sweating, anxiety, tachypnea, and tachycardia or light-headedness, dyspnea, orthopnea, cough, nausea and syncope. An ECG examination is imperative in any patient presenting with this symptomatology. A normal tracing is rare with acute MI.
• Cerebellar bleed
abrupt onset lucid patient
cerebellar tonsillar herniation
should be evacuated as soon as possible before coma ensues
Cerebral bleed develops slowly
early loss of consciousness No herniation No such need
§ The most common cause of chronic AF is valvular disease, followed by congestive heart failure (CHF). The most common anatomic correlate seen in patients with AF (Framingham Heart Study) is an enlarged left atrium.
§ Otosclerosis may progress more rapidly in pregnancyÎRx hearing aids; severe cases may respond to removal of the stapes with implantation of a prosthesis
§ Amylodosis: echocardiogram reveals ventricular walls with a "speckled patternÎ restrictive cardiomyopathyÎ ventricular filling is impaired and the cardiac silhouette may be mildly enlargedÎECG nonspecific arrhythmiasÎ Like all restrictive ds develops into diastolic dysfunction.
• The pulmonary artery catheter/Swan-Ganz catheter allows direct, simultaneous measurement of pressures in the right atrium, right ventricle, pulmonary artery, and the filling pressure ("wedge" pressure) of the left atriumÎ elevated right-sided pressure and low wedge pressure Î Rt ventricular infarct? Causing backing up of venous blood and decreased forward flow, producing a decrease in left ventricular filling, ÎRx aggressive fluid administration.
• A communication between an arteriole and venule in the cecum is a description of a vascular ectasia, also known as an arteriovenous (AV) malformation. This a common cause of painless colonic bleeding in the elderly and may present with acute gastrointestinal bleeding,chronic gastrointestinal bleeding, or iron-deficiency anemia. These lesions may be difficult to demonstrate, as the bleeding may be intermittent or the colon may be so full of blood that the site of origin is obscured. Techniques used to demonstrate bleeding AV malformations include colonoscopy, intraoperative endoscopy, and visceral angiography. Treatment of these lesions is problematic because many patients will subsequently develop new or recurrent bleeding vessels.
• Having difficulty holding and using a writing instrument due to hand and forearm spasms Îno medications, dizziness or loss of consciousness or any history suggestive of a seizure Î focal dystonia of unknown cause.
• CardioversionÎSynchronized electrical cardioversion is the process by which an abnormally fast heart rate or cardiac arrhythmia is terminated by the delivery of therapeutic dose of electrical current to the heart at a specific moment in the cardiac cycle as determined by a compute0r(Pharmacologic cardioversion uses medication) ÎSynchronized electrical cardioversion is used to treat hemodynamically significant supraventricular (or narrow complex) tachycardias, including atrial fibrillation and atrial flutter. It is also used in the emergent treatment of wide complex tachycardias, including ventricular tachycardia, when a pulse is present. Pulseless ventricular tachycardia and ventricular fibrillation are treated with unsynchronized shocks referred to as defibrillation.
So,hemodynamically unstable(loss of consciousness)vetricular tachcardia Îtreat with asynchronous cardioversion.
• HypertensionÎeye tries to protect itself from the hypertension Î arteriolar constrictionÎthickening of the arteriolar walls (producing the broad light reflex)Î arterioles squeeze down too hardÎ superficial foci of retinal ischemia(cotton wool spots)Î hemorrhage and deposits occur because of vessel damage with leakage of contents.Hypertensive retinopathy seen in chronic essential hypertension, malignant hypertension, and toxemia of pregnancy. Rx control of the hypertension. (Practically, progression can be stopped and the hemorrhages will resolve, but the vessel changes remain.)
• Nonproliferative diabetic retinopathy= hemorrhage and exudates in the retina + microaneurysms (visible as red dots).
• Proliferative diabetic retinopathy = nonproliferative diabetic retinopathy +neovascularization with vessel growth into the vitreous.
• Brain-death Îno electrical activity and no clinical evidence of brain function on physical examination (no response to pain, absent cranial nerve reflexes ,pupillary response:fixed pupils, oculocephalic reflex, corneal reflexes), absent response to the caloric reflex test and no spontaneous respirations. But patient without such criteria but with no purposeful activity one week after an anoxic brain injury bodes poorly for a meaningful neurological recovery!(Not a brain death but recovery not meaningful).
• Whenever you see a case with a link to water reservoir/source like cruise/hospital/air-conditioner system and patient developed mental changes + diarrhea + Pneumonia = DDx Legionnaires pneumonia Rx Erythromycin
• Yersinia enterocolitica: Right lower quadrant pain mimicking appendicitis with symptoms of an acute ileitis and diarrhea (In appendicitis patient typically have difficulty moving their bowels). Acquired through the fecal-oral route and diagnosis is based on clinical suspicion and the finding of the organism in stool cultures.
• Campylobacter jejuni: acute onset of either watery or bloody diarrhea consistent with colitis, severe fecal urgency, nocturnal bloody diarrhea Îsigmoidoscopy reveals continuous, symmetric inflammation from the anal verge to the proximal sigmoid colon Î diarrhea in all age groups/peak of incidence is in young childrenÎFecoral spread
• Intentional inhalation of volatile hydrocarbons(model glue, correction fluid, spray paint and gasoline) in a large quantity = "quick drunk": resembles alcoholic intoxicationÎvery high dose ataxia, hallucinations, and nystagmus ÎEncephalopathy is the major chronic morbidity (Hydrocarbons are highly lipophilic leading to CNS damage) Îhigh level of suspicion is needed Îno drug screen test that can detect inhalant hydrocarbons.
• Rubella vaccine ÎGap of 3 months to be pregnant(theoretical risk of exposure to the rubella virus through vaccination)ÎBut if pregnancy occurs within 3 months after vaccinationÎnot an indication or a reason to terminate the pregnancy(Simply woman should be counseled about the theoretical risk).
• Neonatal especially preterm steatorrhea due to smaller bile acid pool Îsubstitute medium-chain triglycerides (MCTs) in the formula for long-chain triglycerides (LCTs)ÎMCTs do not require bile acids for absorption.
• Milestones:
1. 4-years Î draw a four-sided figure (i.e., a square), count to 4, identify four colors, say a four-to
five-word sentence, and draw a picture of a person with at least four parts. (Easily remembered as
4-year-olds do things in 4's.)
2. 5 yrs ÎDrawing a triangle,count to 10, repeat a 10-syllable sentence, and draw a picture of a
person with 8-10 parts
3. 6 yrs ÎBuilding a staircase with cubes,can perform simple addition and draw a person with 12-15
parts.
4. 7- yrs Îability to repeat five digits,can repeat three digits backward, draw a diamond shape, and
draw a person with 18-22 parts.
• Mitral valve prolapse =An apical click followed by a late systolic murmur ÎRx antibiotic before Dental procedure
Mitral and tricuspid regurgitation = produce holosystolic murmurs with relatively uniform intensity. Mitral regurgitation is heard at the apex while tricuspid regurgitation is best heard along the lower left sternal border.
Mitral stenosis= mid-diastolic murmur heard after an opening snap.
• nasal foreign body: frequent sneezing and obstruction(Often misinterpreted as a common cold or allergy) Îinfection develops Îresulting in a purulent and malodorous dischargeÎunilateral involvement
• A saturation of 90% corresponds to an oxygen partial pressure of around 60 mm Hg =Hypoxia needs oxygen
• hepatitis A diagnosis is best made by determination of IgM levels against hepatitis A virusÎacute infection(antibody peaks at 4-6 weeks and does not persist beyond 6 months)while IgG is produced in the primary infection, but for most viral infections, including hepatitis A, it persists for a life time.
• Attention deficit/hyperactivity disorder (ADHD) is characterized by impulsivity, hyperactivity, and inattention lasting at least 6 months and disorder must have started before age 7.
• Cardiac defects:
1. Hypoplastic Lt heart syndrome: underdevelopment of the left cardiac chambers(left atrium and ventricle often exhibit endocardial fibroelastosis), atresia or stenosis of the aortic and/or the mitral orifices, and hypoplasia of the aortaÎ No murmur, precordial hyperactivity(enlarged right ventricle is contracting against systemic pressure), loud second heart sound (because the pulmonary artery acts as the aorta by pumping blood to the systemic circulation through the ductus arteriosus). When the ductus closes, or when the pulmonary vasculature resistance falls, the flow to
the systemic circulation will decrease, causing greatly diminished peripheral pulses. Management includes infusion of prostaglandin E1 and administration of room air while on a ventilator. Prostaglandin E1 may open the ductus arteriosus and restore systemic blood flow.
2. Total anomalous pulmonary venous return ulmonary veins forming a confluence behind the left atrium, and draining into the right atrium ÎComplete mixing takes place in the right atrium Î right-to-left shunt through the foramen ovale to the left side of the heartÎ Often, no murmur is heard Îchest roentgenogram often shows a normal heart size with pulmonary edema. If there is obstruction to pulmonary venous return, as is almost always present with veins draining inferior to the diaphragm, cyanosis can be very prominent.
3. Neonate becomes cyanotic then lost consciousness following feeding or when crying vigorously
Î baby picked her up and held Îinfant regained Î hypercyanotic spells or "Tet spells"ÎTOF DDx Frequent cyanosis and difficult breathing following birth but improves while cryingÎChoanal atresia Rx intubation via oropharynx
• Post infectious Bells palsy:Mostly EBV
• CHF in infant: respiratory distress, tachycardia and/or hyperdynamic precordium, and cardiac enlargement evidenced by echocardiogram. DDx left-to-right shunt (ASD, VSD, PDA, atrioventricular canal, or AV fistula), left-sided obstruction leading to myocardial dysfunction (severe coarctation or AS), or intrinsic myocardial dysfunction (myocarditis, cardiomyopathy, or infarct due to anomalous coronary artery). Rx IV furosemide provide quick symptomatic relief and improve respiratory distress.
• Rx streptococcal pharyngitis is oral penicillin V for 10 days. However, Benzathine penicillin G can be given as a single dose intramuscularly. It is a long-acting antibiotic and can complete the treatment:Prevention of Rheumatic heart Ds in a noncompliant patient
• Patients with sickle cell disease are at risk for infection by Salmonella and other gram-negative bacteria increased risk for acute recurrent Salmonella osteomyelitis. However, even in patients with sickle cell disease, Staphylococcus aureus is still the most common pathogen for osteomyelitis.
• Children <3 years with harsh, barking cough(sounds like a seal),runny nose but no fever or drooling + hoarse with inspiratory stridor Î Acute laryngotracheobronchitis (viral croup)
DDx
1. Epiglossittis Îfever, drooling, muffled voice, cyanosis, and soft stridor.
2. Laryngomalacia Îpersistent stridor that is first noted early in infancy
• Tanner stages:
1. Stage I (0-15yrs): preadolescent breast development with no pubic hair.
2. Stage II(8-15 yrs)breast budding or thelarche + small pubic hair near the labia + growth spurt
3. Stage III :more pubic hair
4. Stage IV (10-17yrs) breast and nipple enlargement with some contour separation of the areola is noted. Hairs adult quality but not distribution.
5. Stage V (12-18 yrs) complete breast enlargement with no contour separation of the areola. Pubic hair is of adult quality and distribution.
• Neonatal Group B Streptococcus (GBS): Early-onset / first week of life: involve the respiratory tract causing pneumonia .Late-onset (weeks 2 and 4): meningitis.
• Long Q-T syndrome (LQTS):50% familial: syncope and sudden death from torsades de pointes (TDP).
1. Romano-Ward syndrome has autosomal-dominant transmission;
2. Jervell-Lange-Nielsen syndrome has autosomal-recessive transmission. (High Mortality)
On ECG Î QT prolongation (QTc averages 0. 49 seconds).
Rx beta-blocker or implantable cardiac defibrillator in resistant cases.
• Child's recurrent leg painsÎBilateral(Organic pain :Unilateral) Îoccurring soon after going to bedÎrelieved from rubbing his legs and kneesÎ no limp and is able to participate in sports activities Î"growing" pains but unrelated to growth(affect 3-10 years).
• Metabolic alkalosis in cystic fibrosis due to excess sweating (summer)infants & dehydration hyponatremic, hypochloremic, metabolic alkalosis
• Breast-feeding jaundiceÎdecreased intake and increased enterohepatic circulation.
• Any ingested toxic substance/overdose presented within 60 mintsÎ Gastric lavage+ Add charcoal if possible
• Hypernatremic dehydration: hypotonic fluid loss (history of diarrhea or vomiting),inadequate supply of mother's milk or high concentration of sodium in mothers milk Î irritable,lethargic infant and have a high-pitched cry ÎComplication like intracranial hemorrhage
• Intussusception usually occurs within the 6 to 12-month-old age group
• Conscious SedationÎ minor procedures like suturing laceration Î able to maintain airway patency, protective airway reflexes and responses to physical stimuliÎUse short-acting or long-acting benzodiazepine (midazolam or diazepam, respectively) by the oral or rectal route for (Intravenous midazolam or diazepam can be used for procedures that produce more intense pain or discomfort, such as repair of complex lacerations, bone marrow aspiration, and reduction of fractures)
• "Do's" and "Don't's." during the seizure episodeÎdon't Put any object into the patient's mouth,do Place the patient on the side,Put a pillow or other soft object under the patient's head,Loosen tight clothing around the neck,Remove sharp objects from the surroundings.After the seizures, caretakers or parents should remain with the patient until he/she is fully alert and allow him/her to go back to the usual activities.
• Child with ecchymosesÎEliminate bleeding abnormalities by coagulation studies ÎNormal studyÎThink about Abuse!
• Triad of thrombocytopenia (hemorrhage may be the presenting complaint), eczema, and recurrent infections (often respiratory)Î Wiskott-Aldrich syndrome(X-linked recessive)Î defects in both T and B cell functionÎvulnerable to pyogenic bacteria, viruses, fungi and Pneumocystis cariniiÎoften died by age 15 and survivors have increased incidence of cancer (lymphoma /ALL) ÎRx splenectomy, continuous antibiotic therapy, IV immunoglobulin, and bone marrow transplantation.
• Severe combined immunodeficiency (Autosomal recessive) Î "bubble boy" disease because its victims are extremely vulnerable to infectious diseasesÎadenosine deaminase deficiency (purine salvage enzyme and deficiency leading to turn off DNA synthesis)ÎLow T/B cells counts.
• X linked SCIDÎmutations in gene encoding the common gamma chain (γc),shared by the receptors for multiple interleukinsÎ affects development and differentiation of T and B cellsÎAll males with the defective gene will have SCIDÎ Females are carriers.
• Bruton agammaglobulinemiaÎCellular immunity is intactÎ mature B-lymphocytes do not formÎgerminal centers are absent in lymph nodes Îinfections after about six months (maternal antibodies have decreased)Îrecurrent pyogenic infections, particularly of the lungs, sinuses, and bones.
• Common variable immunodeficiency syndromeÎClinically same as Bruton’s but onset in late adolescence/young adulthoodÎhypogammaglobulinemia with markedly decreased IgMÎfailure of B-lymphocytes to differentiate into plasma cells Îpatients have an increased risk for B-cell lymphomas, gastric carcinoma, and skin cancer
• Meconium =fetal stool(desquamated cells from the gastrointestinal tract admixed with enough bile to give the soft stool a greenish color)Îdistressed fetus will pass meconium into the amniotic fluid and then may aspirate itÎIn maternal preeclampsia, hypertension, or postmaturityÎaspirated meconium is very irritating to the lungs and causes a chemical pneumonitisÎRx prompt suction of the nasopharynx and mouth
• Kawasaki disease:systemic vasculitis of unknown originÎmucocutaneous lymph node syndromeÎClinical and echocardiographic features remain the basis for diagnosisÎAn (unidentified) infectious origin and a T - cell immune activation ÎFever, bilateral non-exudative conjunctivitis, mucous membrane changes (injected pharynx, cracked lips, or strawberry tongue), extremity changes (edema, desquamation, erythema, or rash), and cervical adenopathy Îmyocarditis, valvular insufficiency, arrhythmias, pericardial effusion, and congestive heart failureÎLeukocytosis and an elevated C-reactive protein are associated with the development of coronary artery aneurysmsÎRx aspirin ,IV immune globulin & Corticosteroids(Controversial:Reduces coronary artery aneurysm?).
• The most commonly abused drug by pregnant mothers is cocaineÎInfants small for gestational age (SGA) and sometimes,microcephaly and neurodevelopmental abnormalitiesÎirritable and cries in high-pitch. increased risk of sudden infant death syndrome & Periventricular leukomalacia.
• Interesting facts that pancreatitis may show normal amylase(Rely more on lipase)
• Interesting facts that Gullain Barre synd may rarely have sensory involvement
• Listeriosis acquired by mothers exposed to unpasteurized dairy products or raw vegetables exposed to cattle or sheep manureÎamnionitisÎabortion, stillbirth or neonatal sepsisÎbrown, murky amniotic fluid Îor Disseminated disease in the fetus can cause granuloma formation (with associated tissue destruction) in many tissues, including liver, adrenal glands, lymphatic tissue, lungs, and brain(granulomatosis infantiseptica)
• Prenatal toxoplasmosis ÎRx Treatment is with combination antibiotic therapy, including pyrimethamine, sulfadiazine, and leucovorin.
• Bupropion Î antidepressant with both dopaminergic and noradrenergic propertiesÎimprove depression and cognitive functioning (term cognition is used in several loosely related ways to refer to a faculty for the human-like processing of information, applying knowledge and changing preferences)Îalso used to reduce Nicotine craving/dependence ÎAny drug with anticholinergic properties might impair cognitive function(even SSRI)
• Propranolol known to occasionally lead to depressive symptoms
• Loosening of associationsÎideas are disconnected and seem to jump from one topic to an unconnected topic. Clang associations ÎWords that rhyme are frequently associated.
Concrete thinking Îpoor ability to think in abstract terms despite normal intelligence.
Tangential thoughtsÎthoughts that go off on a tangent, interviewer is commonly left with the sense that a question to the patient elicited a long string of thoughts that ended up having nothing to do with the original question.
Thought blocking Îoccurs when thoughts and speech halt, often in mid-sentence, as if forgotten. The thought may be picked up later, after a period of apparent confusion.
• Cimetidine known to cause psychiatric effects like delusions and psychosisÎrelated to the effects of cimetidine on the H-2 histamine receptor in the brain.
• Electroconvulsive therapy (ECT) has been safely used in pregnancy. In case of psychotic depression with increased risk for suicide, the situation requires expeditious treatment to protect the mother and fetus, and ECT is the treatment of choice.
• Post-traumatic stress disorderÎRx Sertaline
• Maternity blues is a normal state of sadness, dysphoria, frequent tearfulness, and dependence that about 20% to 40% of women experience in the postpartum period. It is thought to be derived from rapid changes in women's hormonal levels and the stress of childbirth associated with maternity
• Behavioral therapy is the most frequently used treatment in children with enuresis. Dry nights are recorded on a calendar and rewarded with a star as a gift.
• Agoraphobia(fear of open spaces or of the marketplace)is a fear of panic attacks in situations from which it would be difficult to gracefully remove oneself. Behavioral therapy is used to encourage patients to modify their activities.
• Generally conventional antipsychotic + prophylactic anticholinergic agent (benztropine, diphenhydramine, or trihexyphenidyl).is given togetherÎsudden ceassation of anticholinergicÎPpt Extrapyramidal signs like dystonic reaction/torticollisÎRx IM administration of an anticholinergic agent
• Although risperidone is an atypical antipsychotic, it is like conventional antipsychotics in its ability to cause significant elevations in plasma prolactin levels.
• Psychomotor agitation is a series of unintentional and purposeless motions that stem from mental tension of an individual. This includes pacing around a room, wringing one's hands, pulling off clothing and putting it back on and other similar actions. In more severe cases, the motions may become harmful to the individual, such as ripping, tearing or chewing at the skin around one's fingernails to the point of bleeding DDx Psychomotor agitation in major depressive disorder > bipolar depression
• Catatonia include stupor, negativism(motiveless resistance to all attempts to be moved or to all instructions), rigidity, posturing, mutism, stereotypies, mannerisms, waxy flexibility, and catatonic excitement. Catatonia may be associated with schizophrenia (catatonic type), mood disorders (with catatonic features), or general medical condition or Extrapyramidal side effect of drug .
• Nihilistic delusions are false feelings that the self or others do not exist or are destroyed. It is typical for depression with psychotic features. At its extreme, it is called Cotard's syndrome.
• Prescribing antidepressants in bipolar depression may un-mask underlying mania ÎStart mood stabilizer before beginning treatment with an antidepressant
• Panic disorder Rx benzodiazepine like clonazepam or use of cognitive behavior therapy, which incorporates exposing the patient to disturbing stimuli in an attempt to develop coping mechanisms in response to the stimuli.
• Adjustment disorder is exemplified by a set of behavioral or emotional symptoms developing as a response to an identifiable stressor within 3 months after exposure to the stressor. The symptoms are excessive compared with what one would expect from the exposure, and they cause marked impairment in social functioning.
• Any event that affects the vasculature, such as a myocardial infarction or a cerebrovascular accident (CVA), has been shown to increase the risk of major depressive disorder in the months following such an event. Post-stroke mania is a rare phenomenon usually seen in infarctions of right frontal lobe and sometimes other parts of the right hemisphere.
• Pemoline is a sympathomimetic agent approved for the treatment of attention deficit/hyperactivity disorder. Given the rate of reported cases of hepatic failure. Dextroamphetamine is approved for the treatment of attention deficit/hyperactivity disorder. Its main adverse reactions involve the cardiovascular system, the CNS, the gastrointestinal system, and the endocrine system.
• Prevalence of ADHD is estimated to decline by 50 % every 5 years until the mid-20's i.e. older the children get without symptoms of ADHD, the less likely they have the disorder. (Generally manifest before 6-7yrs)
• Mini-Mental Status Examination (MMSE) is a brief instrument designed to grossly assess cognitive functioning. It assesses orientation, memory, calculation, reading and writing capacity, visuospatial ability, and language. The maximum score is 30. can be re-administered periodically to follow progression of dementia.
• prochlorperazine and haloperidol administrationÎ feeling of restlessness & agitation(akathisia)ÎRx lorazepam given IV during administration of the neuroleptic drug.
• The most serious side effect of lamotrigine(adjunct in the treatment of refractory seizures and bipolar disorder) is rash (skin changes that looked like burns.)ÎStevens-Johnson syndrome
• Clozapine is an atypical agent more effective in resistant schizophrenia. It exerts an antagonistic effect on D1 and D4 receptorsÎS/E agranulocytosisÎrequires regular blood count monitoring
• Thyroid nodule? Benign or malignantÎnodule large enough to cause airway or digestive tract obstructionÎ emergent thyroid surgery without further evaluation.
Step-1:TSHÎDecreased =hyperactive nodule=typically benignA
Step-2:TSHÎNormal or elevated TSH = non-functioning or normally functioning nodule. Step-3:Imaging and/or a biopsy to obtain a tissue diagnosisÎultrasoundÎmost useful diagnostic tool fine needle aspirate (FNA)Îresult from an FNA
1. First, the sample can represent benign lesions= no further treatment (unless the lesion continues to grow causing obstruction to breathing or eating, or causing unacceptable cosmetic disfigurement in the neck).
2. Second, the specimen can be a follicular lesion = treated with a surgical removal of part or all of the thyroid gland to determine whether it is a benign or malignant type.
3. Third, the biopsy can show a clearly malignant lesion = treated with surgical removal of the thyroid gland.
4. Finally, the sample can be nondiagnostic = requires a repeat FNA. However, after three nondiagnostic biopsies, a surgical removal of the affected thyroid lobe is usually recommended.
• Approach towards Breast Lump:
1. Nipple discharge: Pathologic discharges are spontaneous, bloody or associated with a mass. These discharges are usually unilateral. The most common cause of pathologic nipple discharge is intraductal papilloma, followed by duct ectasia.10 If a palpable mass is present in association with a discharge, the likelihood of cancer is greatly increased.
2. Dominant breast mass Dx macrocyst (clinically evident cyst), fibroadenoma, prominent areas of fibrocystic change, fat necrosis and cancer.
(a) Solid Masses in Women Less Than 40 Years of Age
1. Physical ExaminationÎ No evidence of mass Îreassured and instructed in breast self-examination.
2. Physical ExaminationÎ physical finding is uncertain Î directed ultrasound examinationÎnot demonstrate a massÎRepeat physical examinationÎ?mammogram (35 to 40 years not in younger)
3. Physical ExaminationÎ dominant mass (? suspicious mass is solitary, discrete, hard and often, adherent to adjacent tissue)Î mammographyÎpathologic diagnosis.
4. Physical ExaminationÎ dominant mass (? Not a suspicious mass or clinically benign)Î discus options of surgical excision or follow-up with the patientÎpatient desires surgical excisionÎno additional testing is done Îpatient opts for further work-upÎan ultrasound examination and fine-needle aspiration are performed to confirm that the mass is benign. "Triple test" (clinical examination, ultrasonography [or mammography] and fine-needle aspiration).
• The size of the lesion must be measured with a ruler at presentation and on subsequent visits to allow an accurate assessment of size over time.
• patient is examined every three or four months for one year to ensure stability of the mass.
(B)Solid Masses in Women More Than 40 Years of Age.
1. Abnormalities detected on physical examination in older women should be regarded as possible cancers until they are documented to be benign.
2. mammography is a standard part of the evaluation of a solid breast mass.
3. In the presence of a dominant breast mass, a normal mammogram should never be considered proof of the absence of breast cancer.
• Premenstrual dysphoric disorder: constellation of physical and emotional symptoms occurring during the late luteal phase of the menstrual cycleÎsymptoms must be present during most cycles in the past year and during at least two subsequent cyclesÎat least five of the following symptoms: depressed mood, marked anxiety, affective lability, decreased interest, decreased energy, sleep disturbance, craving food, feeling overwhelmed, and difficulties concentratingÎinterfere with social or occupational functioning and are not due to other psychiatric or medical disorders.
• Exposure therapyÎa type of behavior therapyÎmost commonly used treatment of specific phobiaÎ desensitizes the patient by a gradual exposure to the phobic stimulusÎRelaxation and breathing control are important parts of the treatment.
• Alprazolam belongs to the group of short-acting benzodiazepines. Even though it has a short half-life, it can produce confusion, disinhibition, and amnestic problems like blackouts in the elderly population. The risk is increased if it is combined with CYP3A inhibitors.
• In pseudodementia of depression, the patient often tends to emphasize disability related to memory loss much more than patients experiencing true dementia.
• Olanzapine is an atypical antipsychotic indicated for the management of psychotic disorders. It is said to be associated with weight gain.
• HIV dementia is characterized by affective, cognitive, behavioral, and motor symptoms and signs. It presents as a subcortical process and is most likely to occur in patients with a CD4 count below 200/mm3. It usually has a slow onset, and, after a period of stability, there can be a precipitous decline. The diagnosis is made when other causes of delirium are excluded; the disease may present with psychosis within HIV dementia. The symptoms are controlled with low doses of neuroleptics.
• Circumstantiality refers to speech that is delayed from reaching the point, characterized by overinclusion of details.DDxTangentiality : patient never gets to the desired goal from the starting point of discussion.
• Patients with disorganized type schizophrenia are likely to exhibit disorganized speech, disorganized behavior, and flat or inappropriate affect. Examples of disorganized thoughts and speech include: loosening
of associations or derailment, flight of ideas, tangentiality, circumstantiality, word salad, neologisms, and clang associations.
• The newer atypical antipsychotics have minimal, if any effect on plasma prolactin concentrations, except for risperidone, which is associated with elevated prolactin.
• A Papanicolaou smear should ideally be a sampling of the transformation zone(adequate sample should show endocervical cells)Îendocervical cells not present?whether the transformation zone was fully sampledÎRepeat the sample if high risk individual Îor after 1 yr if with no high risk and had all earlier pap normalÎEvery woman should have yearly pap smear after first intercourse or 1 8yrs whatever comes earlier
• Rarely struma ovarii is a cause of hyperthyroidism and patients with this manifestation may have symptoms of hyperthyroidism, as well as elevated levels of thyroid hormones and decreased levels of thyroid stimulating hormone (TSH).
• There is no evidence that breast-feeding increases HCV transmission to the baby.
• Postpartum endometritis ÎCesarean section is the major risk factorÎOrganisms ascending from the vagina and causing a polymicrobial infection of the endometrium Î fever and chills, lower abdominal pain, a foul-smelling vaginal discharge and malaiseÎ abdominal tenderness, and uterine tendernessÎRx clindamycin and gentamicin ( prophylactic antibiotics are recommended in all cases of nonscheduled cesarean delivery i.e. a cesarean delivery that is not anticipated like with membranes broke but non-progressing/Breech etc and are given before or after the umbilical cord is clamped)
• Discharge criteria Îpatient should be alert, able to ambulate (if this was her preoperative level of function), able to tolerate adequate oral intake(Patient on IV intake should not be discharged), have stable vital signs, and have satisfactory bowel and urinary tract function.
• Chorioamnionitis (can develop at any time before and during delivery)Îfever and uterine tenderness ÎRx ampicillin or penicillin with gentamicin.
• Asymptomatic bacteriuria in pregnant womenÎassociation with preterm delivery/low birth weight ÎRx trimethoprim-sulfamethoxazole, nitrofurantoin, and cephalexinÎfollow-up urine culture after 10 days of completing the medicationÎtest-of-cure.
• Gestational diabetesÎusually diagnosed by means of oral glucose tolerance testingÎPatients with gestational diabetes and normal fasting glucoseÎtwo major risksÎfetal macrosomia & eventual development of overt diabetes(within the next 20 years)Îwith gestational diabetes and abnormal fasting glucose Îincreased risk of stillbirth.
• Significant mitral stenosis during pregnancy should be monitored invasively using a Swan-Ganz catheter second stage of labor be shortened using forceps or vacuum to prevent excess maternal Valsalva efforts and maternal tachycardia.
• HIV Positive mother Îcombination of ZDV therapy + cesarean delivery decreases the risk of transmission
to approximately 2% ÎAmniocentesis should be avoided, if possible, in the HIV-positive woman.
1. 2% vertical transmission with ZDV + Scheduled CS prior to the onset of labor or rupture
of membranes
2. 8% antiretroviral therapy in mother + Infant
3. 25% when none used
• Constitutional delay is normal pubertal progression at a delayed rate or onset. The average age at menarche is 12 1/2 years, but it may be delayed until 16 or may begin as early as age 10.
• Current recommendations are that pregnant women who will be in the second or third trimester during the flu epidemic season should be given the influenza vaccination.
• "once a cesarean, always a cesarean." This is no longer the case. Some women are allowed to Î approximately 70% of all women attempt vaginal birth after a prior cesarean delivery will be successful.
• Face presentationÎCauses: anencephalic fetus, pelvic contraction, and high parityÎvaginal delivery is possible when the fetus is in a mentum anterior position (i.e., the fetal chin is oriented toward the maternal pubic symphysis.)ÎFetus can flex its head, thereby allowing deliveryÎ Vacuum delivery /Forceps delivery with a non-vertex presentation would be contraindicated.
• The presence of a classic uterine scar (vertical incision into the uterus that extends from the lower uterine segment up into the active myometrial portion toward the fundus of the uterus) mandates elective repeat cesarean delivery when the fetus is mature as patients with a previous classic cesarean delivery have roughly a 10% risk of uterine rupture.
• Oxytocin or Prostaglandin (PGE2) gel is an effective agent to use for labor inductionÎshown to improve the Bishop's score, to shorten the length of labor and delivery, to decrease the amount of oxytocin needed, and to decrease the cesarean delivery rateÎmain complication from its use is uterine hyperstimulationÎincreased frequency of contractions (greater than 5 every 10 minutes) or an increased length of each contraction (greater than 2 minutes) or contractions of normal duration occurring within 1 minute of each other and a non-reassuring fetal heart rate tracing ÎRx IV or subcutaneous terbutaline or IV magnesium sulfate(MgSo4 also most effective medication for seizure prophylaxis in women with preeclampsia) in case of PGE2 or discontinuing the oxytocin (bradycardia to the 80s) or reducing its dosage (where the fetal heart rate tracing is not as non-reassuring)
• Home uterine activity monitoring (HUAM) Î women are monitored at home with a tocodynamometer (a way to measure uterine contractions)Îwill allow for preterm labor to be recognized and treated in its earliest stages Îto prevent preterm births ÎIn practice not been proven to prevent preterm birthÎpossible benefit early recognition of preterm laborÎwould allow for the administration of corticosteroids to bring about fetal pulmonary maturity (Steroid administration in a Diabetic mother may lead to increased dosage of Insulin).
• Fetal scalp sampling (FSS):method of fetal assessment with fetal blood pH ÎWhen the fetal heart rate tracing is not reassuring, FSS can be used to determine the acid-base status of the fetus, which will help with management of the laborÎpH is > 7.25 then the patient may be managed expectantly ÎpH is between 7.20 and 7.25:repeat in 15 to 30 minutesÎpH is < 7.20, steps should be taken to bring about delivery(Acidemia likely to cause damage to the fetus appears to occur at values < 7.00, by using a cutoff of 7.20, there is a margin for error to protect the fetus)
• Forceps and the vacuum extractorÎTo expedite the deliveryÎindications:
1. non-reassuring fetal heart rate tracing,
2. maternal exhaustion
3. maternal contraindications to pushing (such as maternal cardiac disease.
Choice of forceps or vacuum ? ÎForceps may b
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| drtanvir
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Topics: 21
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plz consider this sign (Î ) as an arrow, while reading the notes.
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| Drtweetie
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Topics: 17
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thanks...lot of work there!
___________________
"Our greatest glory is not in never falling but in rising every time we fall." --Confucius
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| hgheith
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Topics: 39
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 Wow, That's alot of notes. Drtanvir Did you make this yourself? If you have taken this exam, How much did these notes help you?
Thanks for sharing!!
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