krsma
Forum Elite
Topics: 40
Posts: 227
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1. Give the mechanism of action
2. Therapeutic uses?
3. Does it induce or inhibit P-450?
4. What are the blood side effects?
5. What are the other side effects?
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| Bela
Forum Guru
Topics: 76
Posts: 412
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Carbamazepine
MOA: blocks post-tetanic potentiation (decreases synaptic responses).
Indic: It's used for all types of seizures, except Petit Mal(Valpro, Ethosuximide), Status Epilepticus (diazepam), and Myoclonic Seizures (Valpro)
S.E.: Aplastic Anemia, Agranulocytosis; must check liver enzymes; diplopia, ataxia. It increases p450. The way I remember it is that, drugs that increase p450 are:
A-Alcohol
B-Benzos
C-Barbs
P-Phenytoin
Q-Quinidine
R-Rifampin
___________________
La vita e bella!
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| krsma
Forum Elite
Topics: 40
Posts: 227
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1. Give the mechanism of action
-reduces propagation of abnormal impulses in the brain by blocking Na+ channels --> inhibiting repetitive action potentials in epilepsy
2. Therapeutic uses?
- partial (simple or complex) seizures, tonic-clonic seizures, and used to treat tigeminal neuralgia
3. Does it induce or inhibit P-450?
-induces the enzyme, therefore, increases metabolism of other antiepileptic drugs
4. What are the blood side effects?
- aplastic anemia, agranulocytosis, and thrombocytopenia
5. What are the other side effects?
-hepatotoxicity, stupor, coma, respiratory depression, drowsiness, vertigo, ataxia, blurred vision, and minor GI irration symptoms like N/V.
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