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web-immunopath5

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po
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07/25/07 - 01:52 PM

A study is performed of outcomes involving patients who received renal allografts. It is noted that patients who received renal allografts with matching to the donor by tissue typing for HLA-DR (Class II) antigens have a low rate of complications. Which of the following immunologic abnormalities is most likely to be diminished by tissue typing?

A Amyloidosis

B Cell lysis by CD8 lymphocytes

C Graft versus host disease

D CD4 lymphocyte activation

E Serum sickness

jean robert
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07/25/07 - 04:13 PM

D

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doc179
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07/25/07 - 05:44 PM

new_n_lost
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07/25/07 - 06:36 PM

D CD4 lymphocyte activation

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po
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07/27/07 - 08:48 AM

(D) CORRECT. Class II HLA antigens are part of the process of CD4 lymphocyte activation. nod

(A) Incorrect. Amyloidosis is a complication from chronic inflammation over many years or from multiple myeloma.
(B) Incorrect. This is a function of class I antigen recognition.
(C) Incorrect. GVHD is not a consequence of renal transplantation, and few if any donor lymphocytes are present in the allograft.
(E) Incorrect. Serum sickness results from antigen-antibody complexes.

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