Jose Decamps
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Which of the following polymerases, in the eukaritic replication of DNA, have the same activity of DNA polymerase I in Prokariotic DNA replication A. Alpha polymerase B. Beta polymerase C. Delta polymerase D. Epsilon polymerase E. Gamma polymerase
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| keepgoing
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alpha??
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| unique1
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Kaplan says , it is unknown in eukaryots.
Alpha and Gamma both have the same activity as DNA polymerase 3 .
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| Jose Decamps
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 ....
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| keepgoing
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my wild guess would be between b and d thn not sure never raed anywhere in books it must en qbank question
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| Jose Decamps
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It is Beta DNA Polymerase, that has 2 functions: DNA Repair and Excise Rna Primer..... That was a question on UW... good one i think 
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| unique1
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Thanks Jose.
According to Kaplan:
DNA polymerase Delta synthesizes the leading strand.
Alpha synthesizes the lagging strand.
Gamma replicates mitochondrial DNA.
Beta and Epsilon participate in DNA repair.
Removal of RNA primers in prokaryots takes place by DNA polymerase 3 and by an unknown enzyme in Eukaryots.
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| keepgoing
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oh thanks jose..its really new b/c in standard books for usmle we dont see or read these nitpicky stuff..well ok wild guess was more close to an accurate answer 
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| Jose Decamps
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According to FA:
Textually it said: DNA Polymerase I excise RNA Primer with 5'---> 3' exonuclease in prokaryotic cells.
According to Step up:
1. Polymerase Alfa performs primase activity like prokaryotic primase.
2. Pol Delta synthesizes the leading strand.
3. Pol Epsilon synthesizes the lagging strand.
4. Pol Beta repairs and excise primers (similar to DNA Pol I)
According to Lippincott:
1. Pol Alpha has primase activity and synthesizes the RNA primer for both leading and lagging strands.
2. Pol Delta appears to elongate the the leading strand.
3. Pol Epsilon elongate the lagging strand.
"Pol Beta activities are analogous to those of E. coli DNA Pol I-- that is, it can, in association with other proteins, EXCISE PRIMERS AND CARRY OUT REPAIR" ( i just wrote it from the book).
4. In prokaryotes "DNA Pol I also has a 5' ----> 3' exonuclease activity that is able to hydrolytically remove the RNA primer."
i hope that these information is useful for you guys ( i don't know if i wrote this sentences correct, but anyway, the most important information is there....
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| mytime
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Wooooooh! Well done Jose! 
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| unique1
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This is soooo confusing 
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| tompat
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what kaplan says is:
delta for synthesis of leading strand.
alpha for lagging
beta and epsilon for reparing.
gamma for mitochondrial m-rna.
so alpha polymerase in eukaryotic has the same function as polymerase 1 in prokaryotic.
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| tompat
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in some cases epsilon polymerase can synthesis leading strand in eukaryotics.
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| Jose Decamps
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I just gave you the answer from 3 different books....
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| dr ruman
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I AGREE WITH U JOSE,ITS POL BETA THAT REPRESENTS POL 1 OF PROKARYOTES
TOTALLY CONVINCED THANKS
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| Ig F
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this is so damn confusing..all the statement seems to be correct.thtz y we can lable them tht the mechanism is unknown in eukaryotes
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