keepgoing
Forum Guru
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An animal is made diabetic by injection of a drug that destroys pancreatic β cells. Removal of which of the
following organs would most likely produce a decrease in blood glucose concentration in this animal?
A. Anterior pituitary
B. Colon
C. Gonads
D. Kidney
E. Pancreas
no guesses but answer with smart explanation its easy...
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| new_n_lost
Politically InCorrect
Topics: 650
Posts: 6,058
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A. Anterior pituitary >> remove the Big Boss then u will have no GH or ACTH cos GH itself is gluconeogenic and ACTH induces Cortisol which is Also Gluconeogenic.
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| keepgoing
Forum Guru
Topics: 62
Posts: 1,673
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NNL u r right ant.,pit removal
The correct answer is A. Two of the secretions of the anterior pituitary affect the sensitivity of peripheral tissues to the action of insulin. Growth hormone has a direct effect on liver and muscle to decrease insulin sensitivity. This may be partly through a growth hormone-induced decline in insulin receptors or to unknown post-receptor defects. In excess, growth hormone is "diabetogenic," and about 25% of patients with acromegaly have diabetes. ACTH indirectly has anti-insulin effects by virtue of the cortisol secretion it evokes. Like growth hormone, cortisol also decreases insulin sensitivity in peripheral tissues. A third anterior pituitary hormone,
TSH, also tends to increase blood glucose levels. In this case, the effect is robably mediated mostly through increased glucose absorption by the gut. Patients with hyperthyroidism can sometimes exhibit a postprandial glucosuria because of excessive intestinal glucose absorption. In diabetic animals, the removal of the anterior pituitary may lower blood glucose by increasing tissue sensitivity to whatever insulin remains.
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| tompat
Forum Elite
Topics: 36
Posts: 305
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ok guys i agree.
but here are some q
isn't glucose comletely absorbed in the intestine? then what wud TSH do?
and just to add 2 cents to the above explanation-
cortisol has permissive action on catecholamines and glucagon so removal of pituitary wud cause hampering the action of glucagon and epinephine,cuz of no acth and hense cortisol.
for GH also t4 is required and there wont be any t4 cuz no TSH.
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