jean robert wrote:
E.
acoustic neuromas.....NF-2....chr 22.
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| new_n_lost
Politically InCorrect
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The correct answer is E.
The patient has bilateral acoustic neuromas, probably due to neurofibromatosis type II (over 90% of patients with NF-2 develop bilateral acoustic neuromas). This condition is a associated with the NF-2, gene, located on 22q (note all the 2's). Patients often develop meningiomas, gliomas, and schwannomas of cranial and spinal nerves.
5q (choice A) contains the APC tumor suppressor gene, which is associated with familial and sporadic colorectal cancers.
13q (choice B) contains the Rb tumor suppressor gene, which is associated with retinoblastoma and osteosarcoma.
17q (choice C) contains both the NF-1 tumor suppressor gene, which is associated with neurofibromatosis type I, and the p53 tumor suppressor gene, associated with many human cancers.
18q (choice D) contains both the DCC gene, which is associated with colon and gastric carcinomas and the DPC gene, associated with pancreatic cancer.
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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