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webpath21

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po
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Topics: 39
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07/20/07 - 12:10 PM

An experiment is conducted in which proliferating cells are subjected to ionizing radiation. The ionizing radiation leads to arrest in a checkpoint that monitors completion of DNA replication. It is observed that there are increased numbers of chromosomal abnormalities in these cells. Which of the following is the checkpoint affected by the ionizing radiation?

A G0/G1

B G1/S

C S/G2

D G2/M

E M/G0

silver
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07/20/07 - 12:20 PM

C S/G2

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SmokyWaters
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07/20/07 - 12:48 PM

late G1...
G1/S

SmokyWaters
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07/20/07 - 12:50 PM

po GREAT WORK>.. I should commend that.... smiling face

nice questions....I am goin to start my pathology from tomorrow...and all these questions made me know where I stand before starting the prep...THANKS A LOT smiling face

what book by the way should I read for pathology|? my seniors told me to read GOLJAN....I have bought it as well :S but I was reading forums which were in favor of BRS....any suggestions? smiling face

and whats webpath?

drhouse
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07/20/07 - 12:51 PM

i think its C... coz once cell enters into G2 phase there is no mechanism to repair the damage

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SmokyWaters
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07/20/07 - 12:54 PM

yes..and there is no mechanism to repair damagh even after G1 :$ or if there is ...please enlighten me

po
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07/20/07 - 12:58 PM

(D) CORRECT. This is the second checkpoint in the cell cycle; ionizing radiation activates this checkpoint, resulting in chromosomal abnormalities in mitosis.

(A) Incorrect. This represents entry into the cell cycle from the resting, non-proliferating state. Connective tissue cells and hepatocytes can be stimulated to enter the cell cycle, but others such as neurons are terminally differentiated and cannot.
(B) Incorrect. This is the cell cycle checkpoint at which defects in DNA are detected to prevent replication with mutations or chromosomal breaks. .
(C) Incorrect. This is the synthesis phase in which there is no checkpoint.
(E) Incorrect. This is the point at which a cell goes back to a resting state.

SmokyWaters
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07/20/07 - 01:00 PM

umm...PO.... I asked u sumfin smiling face

please have a look at my post puleeeeez

po
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07/20/07 - 01:18 PM

SmokyWaters wrote:

what book by the way should I read for pathology|? my seniors told me to read GOLJAN....I have bought it as well :S but I was reading forums which were in favor of BRS....any suggestions? smiling face

and whats webpath?

I dont know what u SHUD read,i think whichever book u r comfortable with only options being RRGOLJAN,BRS,ROBINS;since me too in same situation.
I baught RRgoljan,did 1 read.Before did 1 read of BRS.but bored to read 2nd time from either of them.but everybody says 2read is must disapproval

I wish I had listened to my guts and baught the middle Robins.Thats my honest opinion,dint mean to offend anybody here,sorry sticking out tongue

Though I hav to confess RR is what I will be using.
webpath is FREE ONLINE resource of pathology questions and slides.It is just great that it is FREE, A BIG THANKS TO THEM.Lot of people use it.

http://library.med.utah.edu/WebPath/webpath.html

SmokyWaters
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Topics: 6
Posts: 458

07/21/07 - 10:29 AM

#10

hey THANKSSSSSSSSS po smiling face

it was a bighelp...I guess I would have ended up like you because I also get bored fast....especially FROM BOOKS :P

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