po
Forum Elite
Topics: 39
Posts: 356
|
A 15-year-old boy has had lumps in the right neck for the past 5 months. On physical examination there is painless lymphadenopathy in the right cervical region. One of the lymph nodes is biopsied and on microscopic examination shows many lymphocytes that are large, with clumped chromatin and occasional mitoses. The characterization of this population of lymphocytes as a neoplasm is best accomplished by which of the following methods?
A Immunohistochemical staining identifying leukocyte common antigen
B Gene rearrangement studies that demonstrate clonality
C Flow cytometry indicating a high S-phase
D A differential white blood count showing a lymphocytosis
E Demonstrating fibrosis within the mass by light microscopy
|
| SmokyWaters
Forum Elite
Topics: 6
Posts: 458
|
A
|
| silver
Forum Guru
Topics: 21
Posts: 772
|
A
___________________
Every disaster hides an opportunity.
|
| po
Forum Elite
Topics: 39
Posts: 356
|
I had guessed it right,but IT WAS NOT A
|
| silver
Forum Guru
Topics: 21
Posts: 772
|
C ??
___________________
Every disaster hides an opportunity.
|
| SmokyWaters
Forum Elite
Topics: 6
Posts: 458
|
B
|
| drhouse
Forum Senior
Topics: 21
Posts: 192
|
B??
___________________
everybody can do it.... its just matter of time
|
| po
Forum Elite
Topics: 39
Posts: 356
|
(B) CORRECT. Clonality is a key characteristic of neoplastic cellular proliferations that distinguishes them from reactive proliferations (such as inflammation).
(A) Incorrect. Staining with LCA will only tell you that cells are of leukocyte origin, not whether they are part of a neoplastic proliferation.
(C) Incorrect. Flow cytometry cannot tell you with certainty that a neoplasm is present.
(D) Incorrect. Inflammation could lead to lymphocytosis. Lymphomas are unlikely to have a lymphocytosis.
(E) Incorrect. Fibrosis is a feature of inflammation as well as neoplasia.
|
|
| |
| | | | | | | | |
