po
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A 55 year old male is diagnosed with a non-small cell lung cancer and is given a chemotherapy regimen with multiple drugs. He has an initial response to the chemotherapy, with a decrease in size of the tumor. However, a year later the mass is increasing in size, and mediastinal lymph nodes appear enlarged on chest CT scan. A different chemotherapy regimen is employed, but has no effect. Which of the following mechanisms best explains these events:
A) A sarcoma has arisen from the neoplastic cells
B) The neoplastic cells have become well-differentiated
C) P-glycoprotein levels have become elevated in the neoplastic cells
D) There is viral binding of p53 protein in the neoplastic cells
E) Telomerase activity is absent in the neoplastic cells
Explaination please
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| tompat
Forum Elite
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c
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| tompat
Forum Elite
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these proteins cuz efflux of many anticancer drugs
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| po
Forum Elite
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thanks
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| new_n_lost
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This has become the major cause of Mulit Regime Resistence amongst Cancer Therapy.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| tompat
Forum Elite
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verapamil will nail it
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| tompat
Forum Elite
Topics: 39
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thanks for the q po, keep them coimng
all the best
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| bioguy
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in this case -
are other choices not correct - if so can someone pls explain why in each answer
or - other answers may be true, but C is the best choice
thanks
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??/??/CS pass/??/4USlors/Need Visa - ok, i also need a good USMLE score !
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| new_n_lost
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u want to know y C is the Answer or y the other choices have not been selected as the right answer??
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| bioguy
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why the other choices aren't right?
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??/??/CS pass/??/4USlors/Need Visa - ok, i also need a good USMLE score !
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| bioguy
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i can make some sense out of them being not right but just need expert opinions!!
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??/??/CS pass/??/4USlors/Need Visa - ok, i also need a good USMLE score !
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| SmokyWaters
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C
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| SmokyWaters
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A) A sarcoma has arisen from the neoplastic cells
this is definitely a SMALL CELL LUNG CARCINOMA...it doesnt give rise to sarcoma
B) The neoplastic cells have become well-differentiated
well differentiation will not show as INCREASE in size....
C) P-glycoprotein levels have become elevated in the neoplastic cells
... you already know why
D) There is viral binding of p53 protein in the neoplastic cells
there has been no viral binding noted in this type of neoplasm...secondly...p53 binding hasnt been established in lung cancers...
E) Telomerase activity is absent in the neoplastic cells
telomerase activity is very high in these cells..
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