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Kaplan Qbank USMLE



Author5 Posts
  #1

As part of an experimental study, a volunteer agrees to have 10
grams of mannitol injected intravenously. After sufficient time for
equilibration, blood is drawn and the concentration of mannitol in
the plasma is found to be 65 mg/100 mL. Urinalysis reveals that
10% of the mannitol had been excreted into the urine during this
time period. What is the approximate extracellular fluid volume of
this volunteer?
A. 10 L
B. 14 L
C. 22 L
D. 30 L
E. 42 L

  #2

answer is 14?
------------
V x C = A
------------

V= Volume of the compartment
C= Concentration of tracer
A= amount of tracer


V x 65mg/100ml= 9gr (90% of initial A)
V= 13,8 ==> 14 ?

___________________
Kris2c

  #3

thanks kris..you made it easy for me

  #4

thanks I was confused for a second but I got it.

  #5

no need for formula,
if 10% is excreted; 9gr mannitol is circulating in blood.
mannitol's conc is 65/100ml---) 6,5gr/per liter
6,5gr 1 L
9gr x L
==========
9/6,5 = 14







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