RockSteps
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Hello all. Can someone compare the contrast the follow. for me please:
Membranous Glomerulonephropathy,
Membranoproliferative Glomerulonephritis, and
membranous glomerulonephritis.
I'm sure this concept is confusing for others on this board too, so if we can discuss this, I will greatly appreciate it.
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| RockSteps
Forum Newbie
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Wow..one big party in here.
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| tompat
Forum Elite
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membranous glomerulonephropathy and membranous glomerulonephritis are one n the same.
it's a MCC of nephrotic syn in adults. microscopically there is SUBEPITHELIAL IC deposits
in membranoproliferative there are 2 types
1,type1 :SUBENDOTHELIAL deposits and as the name suggests proliferation of messangium
2.type2 :INTRAMEMBRANEOUS deposits and proliferation of messangium
rest the causitive factors u can see in text
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| RockSteps
Forum Newbie
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hey..thanks for the response. when you say that there is an intramembranous response in MPGN II, where exactly are the deposits? I'll look up the causative factors. I'm having a real hard time understanding renal.
My understanding is limited to:
MCD = fusion of podocytes = rx upon steroids
and so on and so forth. I really don't understand the pathology behind it. Is there anyone who can perhaps discuss renal w/ me over yahoo or something?
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| tompat
Forum Elite
Topics: 36
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intramembranous means right inside the GBM, imagine a cream biscuit where there is cream between two pieces.if wud see it at it's width then u can see the cream , the cream here is the IC deposits.
membranous is related with HBV n type I MPGN with HCV.
if wud come across tram track apperance in q stem more likely it wud be type I MPGN .but u can see it in type II MPGN also.
in type I u will see proliferation of mesangial cells in between GBM and endothelial cells.
u can see the EM pictures in robins patho.
in type II there are auto antibodies against C3 convertase, C3bBb, this anti body is called as C3 nephritic factor.
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