new_n_lost
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How to Differentiate bw Hemophilia A & B & Von Willebrand Disease in Clinical Settings ??
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| new_n_lost
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
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No Answers Cmon Guys
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| new_n_lost
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U cant clinically differentiate Hemophilia A from B but on lab work With the presence or Absence of Factor VIII or Facotr IX.
But a Low Factir VIII with Absence and/or of vW factor suggests a vW as primary disease.
The hallmark of hemophilia is hemorrhage into the joints. This bleeding is painful and leads to long-term inflammation and deterioration of the joint, resulting in permanent deformities, misalignment, loss of mobility, and extremities of unequal lengths. While a male infant can be presented with prolonged bleeding on circumcision.
The history of pt with Von Williebrand may reveal the following:
- Increased or easy bruising
- Postoperative bleeding (particularly after tonsillectomy or dental extractions)
- Family history of a bleeding diathesis
- Bleeding from wounds
- Gingival bleeding
- Postpartum bleeding
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| drhouse
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good,
but isnt it true that hemophilia and VW dis are interrelated??
so clinically sign n symptom may be mix rather then demarcated as u mentioned
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| new_n_lost
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Nope there is a clinical diference and a genetical difference in the Diseases.
Althought the Factor VIII and VW protein r indeed a part of F VIII Complex but they r 2 different entities.
"Clarification of the structure and function of the FVIII molecule (FVIII-C, an X-linked gene product) noncovalently bound to von Willebrand factor (vWF, an autosomal 12p gene product) in plasma clarified the separate roles of FVIII-C and vWF proteins. This led to an understanding of the role of the different components of the FVIII molecule in the physiology of normal hemostasis and to a recognition that hemophilia A and von Willebrand (vW) disease were caused by a deficiency of different proteins in the FVIII complex. "
Emedicine.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| Ig F
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hemopbilia A and B cant be distinguished clinically.......lab work is required...
while vWF disease gives a more aggressive picture as there is a deficiency of vWF factor and in result of this eficiecy factor VIII;c is also low......
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