new_n_lost
Politically InCorrect
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A 54-year-old male with acute lymphocytic leukemia develops a blast crisis. He is treated with intensive systemic chemotherapy.
Following treatment, the patient will be at increased risk for the development of
A. bile pigment gallstones
B. cholesterol gallstones
C. cystine kidney stones
D. struvite kidney stones
E. uric acid kidney stones
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| bioguy
Forum Guru
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guessing, E.
no idea about C. or D.
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| medocuk
IM-RES
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E. uric acid kidney stones. Huge turn over of cells causing increase in Urea hence the need for admisnistring allopurinl to all blast crisis patients?
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| Luckyall
Forum Guru
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E
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| drhouse
Forum Senior
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E
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everybody can do it.... its just matter of time
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| new_n_lost
Politically InCorrect
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The correct answer is E.
Uric acid kidney stones in patients with leukemia are secondary to increased production of uric acid from purine breakdown during periods of active cell proliferation, especially following treatment. Vigorous hydration and diuresis are generally instituted after the diagnosis of acute leukemia is made. Uric acid kidney stones are also associated with inborn errors of purine metabolism, such as gout.
Pigment gallstones (choice A) are associated with hemolytic disease. The incidence of this type of gallstone is not increased in treated leukemias.
Cholesterol gallstones (choice B) are associated with diabetes mellitus, obesity, pregnancy, birth control pills, and celiac disease.
Cystine kidney stones (choice C) are rare; they are found in cystinuria.
Struvite kidney stones (choice D) are associated with infection by urea-splitting organisms, such as Proteus.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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