asmi
Forum Hero
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what is the site of origin of atrial natreuretic factor and what is the MOA ( mech. of action ) ?
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| usmleasr
Forum Guru
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is it atrial myocytes right atrium??..promotes natriuresis..in response to strech of rt atrium..as it assumes volume overload.. :?
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| Bela
Forum Guru
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Hmm, I thought it can be either or (R/L Atria).
It also is a vasodilator, increases GFR (increased V of blood being ejected from heart); decreases renin secretion. It also inhibits Aldosterone??? but can have a direct effect on Na excretion as well.
I remember it because it does everything opposite of Aldosterone.
Correct me if I am wrong, please!
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| asmi
Forum Hero
Topics: 1043
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i too think that it can be from right/left atrium .
:arrow: relased in response to increased pressure in atrium.
:arrow: causes relaxation of vascular smooth muscles ,dilation of arterioles and decrease TPR.
:arrow: causes increased excretion of salt (natriuresis) and water -->reduces blood volume .
:arrow: inhibit renin release .
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