new_n_lost
Politically InCorrect
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First Order Kinetics : Elimination of the Drug is directly proportional to its plasma Concerntration. its dependent on its Half life. First order implies that No matter How much concerntration of the Drug u give it will be eliminated 50% by its First Half- life. Tht means its time dependent. Like if the drug has a half life of 30 mins and u give 2 gms then after 30mins only 1 gm will be left in the plasma. The 50% of active form of the drug that will disappear from the Plasma in a certain amount of time is termed as Half Life.
Zero Order Elimination: This form of elimination is refered to as elimination which is independent of time or concerntration. it will take a linear approach on a graph
I hope i have explained it to u well or atleast i have tried Others can Join in their comments.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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Forum Elite
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First order kinetics means the amount of excretion depends on the amount of drug present. Zero order kinetics means that the amount of excretion is independent of the amount of drug present.
A zero-order rate law for a chemical reaction means that the rate of the reaction is independent of the concentration of any reactant. A zero-order rate law can be observed only if the actual reactant concentrations cannot change as the reaction proceeds, which is uncommon, and so zero-order rate laws are rarely found.
Zero-Order elimination occurs in overdose situations the various processes by which drugs get eliminated are saturated.that is rate of elimination is constant,unlike in first order where rate of elimination dependant on plasma concentration.Drugs that obey first-order kinetics with low doses may obey zero-order kinetics with large doses.
ex.of zero order are-phenytoin,alcohol,salicylates
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