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26 Posts

tompat
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Topics: 39
Posts: 362

07/07/07 - 09:04 PM

#21

to silver,
yes i have read it carefully, it says alcohol wont be there to compete with acetaminophen after a brief abstinence.leaving P450 induced.
but we are talking about what happens if we now give him alcohol?that is what if we treat him with alcohol?

new_n_lost
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Topics: 724
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07/07/07 - 10:15 PM

#22

Ok One Question y do we really NAC i mean wht the Mechanism of NAC ??

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tompat
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Topics: 39
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07/07/07 - 10:44 PM

#23

to replenish glutathion , which wud then combine with the toxic product of acetaminophen metabolism to form a non toxic product

SILVER
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07/07/07 - 11:50 PM

#24

NAC is a precursor of glutathione

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SILVER
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07/07/07 - 11:57 PM

#25

and NAC increases glutathione availability to bind to NAPQI.

In addition, NAC increases local nitric oxide concentrations, and this vasodilatory effect on microcirculatory blood flow enhances local oxygen delivery to peripheral tissues. These vasodilating effects decrease morbidity and mortality even in the setting of established hepatotoxicity.

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SILVER
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07/07/07 - 11:59 PM

#26

tompat wrote:
to silver,
but we are talking about what happens if we now give him alcohol?that is what if we treat him with alcohol?

This has already been discussed in posts # 12 & 13

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