jean robert
Forum Guru
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A 75 y.o. woman is seen in the emergency room with fratured arm. Physical examination revealed multiple bruises and perifollicular hemorrhages, peridonitis and painful gums.Her diet consist predominately of weak coffee,bouillion,rolls and plain plasta.Lab results indicated mild microcytic anemia.
Which of the folowing enzymes should be less active than normal in this patient?
a.-Homocysteine Methyltransferase
b.-gamma glutamyl carboxylase
c.-Dihydrofolate reductase
d.-ALA synthase
e.-Prolyl hydroxylase
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| paheli
It'sAllAboutGoodKarma
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gotta be e.
vit C is required for collagen synthesis.
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| new_n_lost
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No Clue  
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| doc179
Forum Guru
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its scurvy, E
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| jean robert
Forum Guru
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Posts: 676
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 E
This patient has many signs of scurvy from vitamin C deficiency. The diet, which contains no fruit or vegetable, provides little vit. C. Prolyl hydroxylase requires vit. C, and in the absence of hydroxylation, the collagen alpha chains do not form stable, mature collagen.
The anemia is due to poor iron absorption in the absence of ascorbate.
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| po
Forum Elite
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got to know all about collagen,given best points in FA.
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| lakreol
Forum Newbie
Topics: 2
Posts: 11
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 since u have explained to role of vitamin c.
What is the role of copper in mature collagen production?
what does the lack of Copper led to?
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| Jackofknives
Ipwnpoker.com
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Posts: 737
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poor Cu2+ distribution decreases hydroxylysine, this in turn gives cutis laxa or occipital horn syndrome, deformities are as the names imply.
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