 | Prep for USMLE |
| Forum | Resources | New Posts | Register | Login | » |
|
| Author | 18 Posts | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
AngelT
Forum Newbie Topics: 34 Posts: 102 |
A researcher develops a specific antibody to the complement component C3b. Assume that IV administration of the Ab prevents the biological effects of C3b. Which of the following disease conditions would be most likely to be ameliorated by the administration of this Ab to a patient? A-Acute Glomerulonephritis B-Hashimoto Thyroiditis C-Lupus Erythematosus D-Myasthenia Gravis E-Tuberculosis
|
Prep4USMLE.com
|
Advertisement
|
|
SILVER
| DoWhatYouGotToDo!  Topics: 56 Posts: 1289
A-Acute Glomerulonephritis
|
AngelT
| Forum Newbie Topics: 34 Posts: 102
The answer is C. But I still didnt understand why it could not be A???
|
SILVER
| DoWhatYouGotToDo! Topics: 56 Posts: 1289
can you post the expln. that is given for this question? where is it from?
|
po
| Forum Elite Topics: 39 Posts: 355
A-Acute Glomerulonephritis-type 2cytotoxic B-Hashimoto Thyroiditis-type 2 cytotoxic C-Lupus Erythematosus-immune complex type 3 D-Myasthenia Gravis-type 2 cytotoxic E-Tuberculosis-cell mediated type 4 Am I right?can this some clue?just thinking.
|
AngelT
| Forum Newbie Topics: 34 Posts: 102
GNDA- type III GoodPasture- type II cytotoxic Myasthenia gravis- type II not cytotoxic Tuberculosis- type IV Hashimoto - type IV The confusion is about the letter A that could be II or III depending on the type of glomerulonephritis.
|
AngelT
| Forum Newbie Topics: 34 Posts: 102
LES- type III
|
paheli
| It'sAllAboutGoodKarma  Topics: 207 Posts: 2793
in SLE, there is excess Ag-Ab complexes that is deposited in various parts of the body. suppressing the action of C3 in that, incl opsonication etc will result in decreased deposition of the complexes.
|
doc179
| Forum Guru Topics: 67 Posts: 1213
right, the immunecomplexes activate the classic complement pathway and hence when you inhibit the c3b you prevent damage to self tissue and ameliorate the disease
|
MALUKO
| Forum Newbie Topics: 0 Posts: 7
Type III hypersensitivity in SLE is characterized by deposition of immune complexes specially in the kidney. If you block the function of C3b you will with withdraw the process of getting rid of the immune complexes from the body. So, you will probably end up with an increased amount of immune complexes. C3b is an opsonin and will mediate phagocytosis of the immune complex and vasodilation. Correct me if I'm wrong.
|
MALUKO
| Forum Newbie Topics: 0 Posts: 7
doc179 wrote: right, the immunecomplexes activate the classic complement pathway and hence when you inhibit the c3b you prevent damage to self tissue and ameliorate the disease I think the damage is due to the immune-complex themselves and the not the action of c3b which is to prevent the immune-complex depositions.
|
doc179
| Forum Guru Topics: 67 Posts: 1213
damage is not due to the deposition of immunecomplexes but because of the activation of the classic complement pathway by them which attracts the PMNs and other defense mechansims to get rid of them, hence when you block C3b , you basically alleviate the immune response towards the immunecomplexes and hence decrease damage to the tissue.
|
yoga
| Forum Guru  Topics: 73 Posts: 637
E
|
yoga
| Forum Guru Topics: 73 Posts: 637
C  ? DONT WE HAVE IMMUNE COMPLEX DEPOSITION IN GLOMERULONEPHRITIS ALSO?
|
ok07
| Forum Newbie  Topics: 0 Posts: 1
C ?
|
hope4dabest
| Forum Guru  Topics: 23 Posts: 456
Pathophysiology: Glomerular lesions in acute glomerulonephritis are the result of glomerular deposition or in situ formation of immune complexes. On gross appearance, the kidneys may be enlarged up to 50%. Histopathologic changes include swelling of the glomerular tufts and infiltration with polymorphonucleocyte. Immunofluorescence reveals deposition of immunoglobulins and complement SOURCE--eMEDICINE AGREED WITH CHOICE C BUT CAN SOMEBODY PLZZ EXPLAIN Y ITS NOT CHOICE A ALSO????
|
sfk
| Forum Elite Topics: 47 Posts: 296
angel, where from is this question? and whats the explanation given?
|
tompat
| Forum Newbie Topics: 64 Posts: 561
may be because u need few c3b to be free to cause damage in AGN but in SLE u require more of c3b. JUST A WILD GUESS
|
|
| | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
This thread is closed, so you cannot post a reply.
 Similar forum topics37 yr old man with confusion... Confusion Acebutolol confusion | Related resources |
Advertise | Support | Premium | Contact |
Your Privacy Choices