cirus
Forum Guru
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In UW there was a quest on the target INR with pulm embolism
& the ans was 2-3 times the normal
on the other hand in Kaplan it is 1.5-2 (which was my answer for the quest & ofcourse it was wrong)
They also did mention that most Warfarin indications targets INR 2-3
So which one to follow??
I surched it on the internet: --American Academy of Family Physicians website
this is what I got
Warfarin
Once acute anticoagulation is achieved, warfarin is the drug of choice for long-term therapy to prevent clot recurrence. A standard warfarin protocol includes starting treatment at 5 mg per day and titrating the dosage every three to seven days to achieve an INR between 2.0 and 3.0 Attempts have been made to maintain patients at an even lower INR (between 1.5 and 2.0), but results have been contradictory. Unless further data show otherwise, anticoagulation with a standard INR goal of 2.0 to 3.0 should be used.
So thats another one to change in Kaplan notes, it may be small, but it sure is imp
Oh & the heparin PTT should be 1.5-2.3 times normal..
Good luck
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| prathapdoctor
Forum Elite
Topics: 12
Posts: 406
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yes cirus, In CMDT,its given that INR should be maintained at 2to3 in PE.
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| doyoudig
Forum Guru
Topics: 144
Posts: 613
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what the normal INR for Heparin?
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| sprint123
Forum Guru
Topics: 129
Posts: 870
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For Heparin it is 1.5-2 times the normal!
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| cirus
Forum Guru
Topics: 108
Posts: 740
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INR is related to the PT & not the PTT, so as Heparin only affects the PTT( Intrensic pathway), it has no role on the INR, while warfarin acts on the PT( Extrensic Pathway) so it increases the INR
So for follow up Heparin---> PTT
Warfarin ----> INR ( i don't know the formula to calculate it but, u don need it for the test)
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| tongsaa
Forum Junior
Topics: 15
Posts: 52
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In JMC, Philadelphia, the standard INR that they use is 2-3.
U r right, INR is defined as PT(pt)/PT(ct), heparin has nothing to do with PT at all, and the therapeutic PTT for heparin is 50-70s.
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