usmleasr
Forum Guru
Topics: 105
Posts: 970
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A pharmacy fellow is trying to determine what the plasma concentration
of an experimental antiarrhythmic agent (Drug X) will be at steady-state
. A continuous intravenous infusion of the agent began 6 hours earlier
at a rate of 3 mg/min. Drug X has a half-life of 3 hours, a volume of
distribution of 120 L, and a clearance of 0.6 L/min. If the rate of
infusion remains constant, what will the plasma concentration be at
steady-state?
A. 0.005 mg/L
B. 0.4 mg/L
C. 2.0 mg/L
D. 5.0 mg/L
E. 40.0 mg/L
F. 200.0 mg/L
explain me the formula used please.. :roll:
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| webjeee
Forum Guru
Topics: 99
Posts: 350
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5.0mg/L
clearance equals input:
0.6L/min=3.0mg/min
so concentration=3.0/0.6=5.0mg/L
the half life doesn't matter, because it only account for 3.0mg*(0.5) to 179(power)
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