Jackofknives
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Two dissimilar inbred strains of mice, A and B, are crossed to yield an F1 hybrid strain, AB. If adult AB spleen cells are injected into a newborn B mouse, which one of the following is MOST likely to occur?
A) the spleen cells will survive without any effect on the recipient
B) the spleen cells will survive and induce tolerance of strain A grafts in the recipient
Explain your answer for Pete's sake or don't reply at all!
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| po
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may be B,
since you are injecting into newborn[ B mouse]
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| Jackofknives
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Now, how does matured lymphocytes induce tolerance in a newborn?
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| po
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as a beginner in immunology this is what I thought would occur; they dint mention matured T cells,since it is spleen cells[ spleen lacks lymphatics];it would be like any other body cell.
Have a look at slide 8 from this link,
http://www2.umdnj.edu/mgenmweb/courses/ccimmu/Lec...
And further got this info,
Newborns lack IL2,so they can be induced tolerance;that is if you give IL2 with these cells probably they wont develop tolerance.
from;
http://www.blackwell-synergy.com/doi/abs/10.1111/...
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| unique1
InGodITrust
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Nice discussion .
Central tolerance takes place by negative selection and colonal deletion.
Peripheral tolerance takes place by :
1 : Engaging Fas on the Tcell surface to FasLigand on other Tcell sruface. This causes apoptosis of T cells, called AICD (activation induced cell death)
2 : Production of IL-10 and Trasforming growth factor beta by suppressor T cells .
3 : Lack of co-stimulatory molecules which causes anergy.
I would like to discuss it further . What next please ?
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| Jackofknives
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I think the original experiments were done in cattle, quite some time ago.
Basically, the exposure of mouse B to A antigens via AB splenocyte transfer is what induces the tolerance. The mechanism of this type of tolerance induction is poorly understood. In light of recent advances, it is plausible to assume that there is induction of host CD4+CD25+Foxp3+ T regulatory cells, Tregs, that recognize antigens from strain A as well as strain B. Although Tregs are antigen specific, they suppress the immune system in a nonspecific manner. So, Tregs from the donor probably would be the cells responsible for tolerance. The question is, will Tregs survive very long in the host? The Tregs will be histoincompatible with the host and will eventually be rejected. So the situation may simply be such that the donor cells act as a source of antigen to which the donor develops tolerance, and may not be the result of donor cell activity.
Tolerance is a very complex topic which is far from completely understood. Whether or not this has been proven, neither I nor my PI know.
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| spinal shock
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B COZ the immune response of the host isnt well developped yet it will respond but not so severe to induce rejection just tolerance
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