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Prep4USMLE Forum » USMLE Step 1 Forum » Immunology Forum

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Jackofknives
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06/26/07 - 09:53 AM

A kidney biopsy specimen taken from a pt with acute glomerulonephritis and stained with fluorescein-conjugated anti-human IgG antibody would probably show

A) No fluorescence

B)Uniform fluorescence of the glomerular basement membrane

C) Patchy, irregular fluorescence of the glomerular basement membrane

D) Fluorescent B cells

E) Fluorescent macrophages

Explain your answer for Pete's sake!

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new_n_lost
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06/26/07 - 01:09 PM

C) Patchy, irregular fluorescence of the glomerular basement membrane

I chose this cos Choices A, D, E dont Fit the Acute GN While Choice B is characteristic for Anti-GBM disease Linear Pattern. the Only choice which gives off a lumpy-bumpy/ granular appearence is choice C

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SILVER
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06/26/07 - 02:02 PM

C...same reason as nnl

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po
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06/26/07 - 03:43 PM

Jackofknives
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06/27/07 - 01:54 AM

You guys are fantastic. Your Moms will be proud!<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />

Accumulations of immune complexes cause AGN. That’s why you get a patchy, irregular fluorescence pattern as the dye is seen on each accumulated group of complex.

B is more suited for Goodpasture bc the AB specifically target the basement membrane.

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drduck
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06/27/07 - 02:03 AM

not one of the most difficult ones......
anyone can rule out......A,D,E
not at all related to the disease....
B and C......
it has to be C......irregular...patchy

Jackofknives
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06/27/07 - 03:56 AM

Sure sure, but the studying process is a not a guessing game, that you can do at the exam. 50% chance to get things right is not good enough. Its very important that you know the CAUSATION of AGN in order to get why C is correct and B is not.

Edited by Jackofknives on 06/27/07 - 04:03 AM

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06/27/07 - 11:37 AM

Jackofknives wrote:
Sure sure, but the studying process is a not a guessing game, that you can do at the exam. 50% chance to get things right is not good enough. Its very important that you know the CAUSATION of AGN in order to get why C is correct and B is not.

excellent point!

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