me007
Forum Guru
Topics: 72
Posts: 803
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explanation wanted
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| doc179
Forum Guru
Topics: 67
Posts: 1,217
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is it B?
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| me007
Forum Guru
Topics: 72
Posts: 803
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nope
it would be too simple 
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| Jackofknives
Ipwnpoker.com
Topics: 91
Posts: 700
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Yea superantigen.
Would be E, bc superantigen binds to Beta chains on TCR and alpha-chains on MHC class II. So all TH1s with similar beta chains regardless of specificity are activated at once.
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| unique1
InGodITrust
Topics: 19
Posts: 1,407
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E
Pyrogenic (erythrogenic) toxin of Streptococcus pyogenes is a superantigen. It superstimulates a large number of Tcells by binding to all TCRs which display a particular variable region on the beta chain (as many as one in five T ells carries the same variable beta subunit). This results in a widespread cytokine mediated pathology analogous to shock induced by lipopolysaccharides from gram negative bacteria.
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| sherry39
Forum Junior
Topics: 3
Posts: 105
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bb coz they r nt talkin of tsst;;;it s the immunologic response to an agent
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| tompat
Forum Elite
Topics: 36
Posts: 312
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E
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| spider
Forum Newbie
Topics: 0
Posts: 10
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It is B..... Concept is all CD4 T cells recognise Antigen +Class2
E does not fit for super antigen behaviour anyway..
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| Ig F
Forum Elite
Topics: 3
Posts: 439
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b and e both seemz to be right....which one is the correct answer guyz??????
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| GoodGirl
.
Topics: 93
Posts: 1,200
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I have seen this Q in Kaplan, yes the anwer is E, Str. pyogenes exotoxin mediated toxic shock.
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| macintosh
Forum Elite
Topics: 38
Posts: 178
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Checked Kaplan Immunology lecture notes. The correct answer is indeed "E".
Because superantigens bind outside of the antigen bindng cleft, they activate any clones of T cell expressing a particular variable beta sequence and thus cause polyclonal activation of T cells, resulting in overproduction of IFN-gamma.
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