edie
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Topics: 26
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Give the DOC for:
1. Hirsuitism in PCOS
2. Tourette syndrome
3. Tx of Torsades des Pointes
4. early Parkinson's disease
5. Hyperprolactinemia
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| me007
Forum Guru
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1. spironolactone
2. haloperidol
3. Mg, K
4.levodopa/carbidopa(?)
5. bromocriptine
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| new_n_lost
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1. Hirsuitism in PCOS >> OCPs or leuprolide
2. Tourette syndrome >> Molindone & Antipsychotics eg Haloperidol, Thioridazine
3. Tx of Torsades des Pointes >>> Acute Form IV Mg Sulphate; Congenital form Beta Blockers which r contraindicated in the Acute setting
4. early Parkinson's disease >>>>> Bromocriptine Dopamine Agonists
5. Hyperprolactinemia >>>> Bromocriptine Dopamine Agonists
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| edie
I can, and I will.
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Yes, all are correct, but for #4, more specifically looking at selegiline as Tx for early PD. Thanks, Me007 and NNL 
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| drduck
Forum Guru
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A........OCPs
B........haloperidol
C.......I/V MgSO4
D.......??????????
E.......bromocriptine
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| edie
I can, and I will.
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1. spironolactone vs OCPs??? I was thinking spiranolactone, comments?
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| me007
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#4 actually pramipepexole and ropinerole (Kaplan is a source)
OCP will block production of androgens by blocking LH and should be used for Tx in POS
spironolactone block at receptor site - Tx for hirsuitism, but i don't remember what else can cause hirsuitism
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| new_n_lost
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me007 wrote:
#4 actually pramipepexole and ropinerole (Kaplan is a source)
OCP will block production of androgens by blocking LH and should be used for Tx in POS
spironolactone block at receptor site - Tx for hirsuitism, but i don't remember what else can cause hirsuitism
Dopamine agonists (bromocriptine, pergolide, pramipexole, ropinirole) can be used as monotherapy to improve symptoms in early disease Ref Katzung
Spironolactone is given to Females who intend to get pregnant in the near future Otherwise OCPs take care the rest of them.
Finasteride is a 5-alpha-reductase inhibitor which is used in women who r post menopausal
Flutamide, new therapy, is a potent nonsteroidal selective antiandrogen without progestational, estrogenic, corticoid, or antigonadotropin activity. it is effective as therapy for hirsutism (and also acne); flutamide is expensive and has caused fatal hepatitis.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| me007
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still have lil misunderstanding concerning fenasteride.
is it DHT cause hirsuitism or testosterone or both?
if mostly testosterone, how fenasteride going to help?
also 5-alfa reductase is tissue specific, is this enzyme exist in women?
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| new_n_lost
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Dihydrotestosterone is the androgen that acts on the hair follicle to produce terminal hair. This hormone is derived from both the bloodstream and local conversion of a precursor, testosterone. The local production of dihydrotestosterone is determined by 5-alpha-reductase activity in the skin. Differences in the activity of this enzyme may explain why women with the same plasma levels of testosterone can have different degrees of hirsutism.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
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me007 wrote:
also 5-alfa reductase is tissue specific, is this enzyme exist in women?
It Exists  
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
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http://www.emedicine.com/med/topic1017.htm
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| edie
I can, and I will.
Topics: 26
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Thank you for the comments and discussion
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