AngelT
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A 12 year old boy presents to a neurologist with rigidity, bradykinesia, an intention tremor, and an uncoordinated gait. Small deposits are seen in the cornea upon close examination. Genetic testing shows a mutation in the short 5´UTR region of the gene associated with this disease. Interestingly, another gene X was recently discovered on the opposite non-coding strand of the disease gene. The translation start codon of the disease gene is located near the end of the first exon of gene X. The polymorphism described will most likely be complementary to which of the following?
a) 3´UTR of gene X
b) 5´UTR of gene X
c) First exon of gene X
d) First intron of gene X
e) Last exon of gene X
f) Last intron of gene X
I didnt understand this question! ; (
Could someone help me please? Thanks !
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| doc179
Forum Guru
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is the answer D? if thats the answer then I will try to explain.
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| peraspera
Forum Elite
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C??
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| AngelT
Forum Senior
Topics: 30
Posts: 100
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Yes. The answer is D. Could you explain to me please?
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| doc179
Forum Guru
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Posts: 1,217
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5'-----------------------------------------3' this is the strand of DNA that is mutated
' '
' '
' ' say first AA,methionine
'
mutation
3'-----------------------------------------5' this is gene X which is normal.
'----' this is the length of the first exon on the hnRNA shown beolw
3' -------5' hnRNA of the starnd that has mutation.
' '
' '
' ' the translation start codon which is at the end of first exon.
'
when approximated from the mutated gene this is where the mutation is complementary to which is the first intron. the hnRNA is taken into consideration as it is the exact copy of geneX and whenever in the qn they mention gene X, if you think about the hnRNA ( not mRNA cos thats not the exact copy of gene X as that does not contain introns ) it would be easy to answer.
Edited by doc179 on 06/17/07 - 11:16 AM
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| doc179
Forum Guru
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eeeiks, I dont like it, the lines did not approximate as I wanted them to .
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| AngelT
Forum Senior
Topics: 30
Posts: 100
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Hi doc179! Thanks a lot!!! I got it now. ; )
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