RayBerg
Forum Senior
Topics: 32
Posts: 150
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I don't remember where I got this from but I have transcribed in my FA that in Minimal change disease you lose the filtration barrier to albumin, but not globulin. Does anyone know why?
I understand that we're probably losing the anionic charge barrier, but why are we not losing globulins? Is it because globulin's MW is much more than albumin? Also, what effect does fusion of podocyte foot process have on filtration/other renal functions?
Thanks.
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| drduck
Forum Guru
Topics: 82
Posts: 523
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concept is simple.....
in minimal change....there is no gross or microscopic abnormility....only thing which makes this disease so important is loss of foot process.....
which is evident only on electron microscopy......
this foot plate usually aquires a partial negative charge compared to rest of the structures.....and so anions that are negative charged particles insipite of being very small.....thats the irony....like albumin are not able to pass through....
but this doesnt mean large molecules like gamma globulin can easily pass....
rather they require a large anatomical defect to pass through...so u just cant compare albumin and globulins....cos the mechanism of filtration are seperate ....one is charge dependent and other size dependent...
also in normal glomerulus.....particles of size of albumin but of opposite chage will get filtered easily or rapidly....as compared to neutral particles...
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