whournameiz
Forum Senior
Topics: 40
Posts: 94
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Rheumatoid arthritis. treatment given. Developed bone marrow suppression.what drug can
be added to prevent this?
A) folic acid b) Vit B 12 c) leucovorin d) vit C
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| new_n_lost
Forum Hero
Topics: 720
Posts: 6,309
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c) leucovorin
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"never argue with a fool, they'll bring you down to their level and beat you with experience" FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| whournameiz
Forum Senior
Topics: 40
Posts: 94
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can u explain
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| epica
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treatment was given---methotrexate----
developed bone marrow suppression.What drug can
be added to prevent this---leucovorin
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| new_n_lost
Forum Hero
Topics: 720
Posts: 6,309
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the Treatment for RA was Methotrexate and the bone marrow suppression which results from it is stopped by giving Leucovorin. This called is Leucovorin Rescue. Leucovorin is formyl tetrahydrofolate which accumulates in the normal cells more than neoplastic cells thus it bypasses the step of dihydrofolate reductase which is inhibited by Methotrexate.
___________________
"never argue with a fool, they'll bring you down to their level and beat you with experience" FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| epica
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"bypasses the step of dihydrofolate reductase which is inhibited by Methotrexate".
 Yep...
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| drduck
Forum Guru
Topics: 82
Posts: 523
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leocovorin........
increases availability of substrate so even if DHFR blocked....bone marrow supression doesnot occour....as there is bypassing of that step.....
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