ssrpk wrote:
don't mix the two up, corticosteroids disrupts the negatiove feedback effect of cortisol on ACTH, but don't disrupt the negative feedback effect of aldosterone, now its is another issue corticosteropids have themselves some weak mineralocorticoid effects and thus can cause salt and water retention with hypokalemic alkalosis, but this effect is independent of the effect of cortisol on ACTH.
ans yes zona glomerulosa won't atrophy.
post-op aldosterone should increase anyway.
surgery is a stressful event and so the dosage requirement for steroids are higher during such episodes and if the increase in the dose is not employed then because of adrenal atrophy due to long term use of exogenous steroids, patient can develop severe adrenal crisis which is a life threatening event.
That was the whole point ...to talk about adrenal crisis !
Good job, ssrpk ! I have nothing to add !
|
| new_n_lost
Politically InCorrect
Topics: 650
Posts: 6,061
|
Its the Basic Concept of Adrenal Gland Physiology took me a long to get that one too. ACTH does act on the Zona Fasiculata and Reticularis and not on the Zona Glomerulosa as per Kaplan Notes esp the Diagrams
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
|
| |
| | | 
