DrVirgo
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Which of the following is most strongly associated with the development of hepatocellular carcinoma?
A. Aflatoxin exposure
B. Hemochromatosis
C. Hepatitis B Virus infection
D. Opisthorchis infection
E. Thorotrast exposure
Are the others associated as well?
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| Justice
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A. Aflatoxin exposure
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| khorshid
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A ( yes all the rest are associated also I think Hepatitis B and Hemochromatosis more than the other two)
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| prathapdoctor
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I think Hemochrmatosis is more strongly associated with hepatocellular car than others. Dont forget to put the answer to this question.
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| oggn
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Asia-Hep B
In western countries and japan-Hepc and Alcoholic cirrosis and rest after them.
Reference-CMDT
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| robin082006
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C
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| krsna
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i think its C...read it somewhere!!most probably UWORLD!!
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| DrVirgo
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Answer C. Hepatitis B Virus infection
is the MOST COMMONLY implicated etiologic factor, both worldwide and in the US.
Other important risk factors for hepatocellular carcinoma would be alcohol abuse, hemochromatosis, and aflatoxin exposure.
Opisthorchis and Throtrast can predispost the patient to Cholangiocarcinoma, not hepatocellular carcinoma.
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| Justice
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DrVirgo wrote:
Answer C. Hepatitis B Virus infection
is the MOST COMMONLY implicated etiologic factor, both worldwide and in the US.
Other important risk factors for hepatocellular carcinoma would be alcohol abuse, hemochromatosis, and aflatoxin exposure.
Opisthorchis and Throtrast can predispost the patient to Cholangiocarcinoma, not hepatocellular carcinoma.
I am sorry if I am wrong, but "most strongly associated" and "MOST COMMONLY implicated" are two different statements, at list to me...
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| prathapdoctor
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very good point made my justice
there is no doubt that HEP B is the most common risk factor, but among all what is the strongest risk factor?
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| DrVirgo
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We are talking about risk factors or etiologic factors here so in the question "most strongly associated with the development of" indicates the same thing as "most commonly implicated".
At least thats what I got from the question.
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| prathapdoctor
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no, answers must differ from most common risk factors to strongest risk factors.But some cancers both may be same. I am really confused regarding this topic.
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| Justice
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DrVirgo wrote:
We are talking about risk factors or etiologic factors here so in the question "most strongly associated with the development of" indicates the same thing as "most commonly implicated".
At least thats what I got from the question.
Some clarifications:
if I drive the car being drunk, the alcohol (as well as my stupidness) are risk factors for getting in crash... If I get in crash being drunk, would alcohol be the etiologic factor of my death??? No, it will be a blunt trauma of chest/head/abdomet/etc... So, there is clear difference between the above two...
In addition, Hep B should be a chronic infection, that does not occur every time, but with aflo there is 90% association... If one put "chronic Hep B" and "hep C", I will agree with him...
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| DrVirgo
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I see what you are saying. When I did the question, I chose A as well, but that is the wrong answer!
I didn't make up this question, so maybe it could have been worded better.
The explanation anyway is as follows:
Hepatocellular carcinoma usually develops in the setting of cirrhosis because of a variety of damaging agents. By far the most commonly implicated etiologic factor, both worldwide and in the US is infection with Hepatitis B OR C.
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| khorshid
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I think this question is not a good one really( or at least the answer), Yes most people who have hepatocellular carcinoma had Hep B or C, because these two are common relatively, but does anyone who has hep B get HC carcinoma, NO! Actually a few get it. But HC happens a lot in areas where they are exposed to aflatoxin. So I agree with prathopdoctor and Justice
But thanx for great questions DrVirgo, Please keep posting them
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