new_n_lost
Politically InCorrect
Topics: 650
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hodgkins lymphoma ???
will search for it , from wht i can recall this was undocumented finding rather controversial finding in HL pts
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| new_n_lost
Politically InCorrect
Topics: 650
Posts: 6,058
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yup its called Pel Ebstein Fever as the 2 physician found it coined the name.
Hodgkin lymphoma (HL) is an unusual lymphoma that can manifest with constitutional symptoms (eg, fever, weight loss, night sweats) termed B-type symptoms. The periodic fever associated with HL is known as the Pel-Ebstein fever.
The classic description is of a relapsing, high-grade fever that can reach 40-40.5°C (105-106°F) and has a periodicity of 7-10 days. The fever spikes are abrupt in onset and resolution. The fever spikes overlie a temperature baseline that never quite reaches normal.
The etiology of Pel-Ebstein fever is thought to be cytokine release. Cytokines known to be released by Reed-Sternberg cells include interleukin 13, macrophage colony-stimulating factor, transforming growth factor-alpha, interleukin 10, and the T cell–directed CC chemokine thymus- and activation-regulated chemokine. Monocyte chemotactic protein 1 and interleukin 8 have also been detected at increased levels in HL tissues.
Pel-Ebstein fever has been used as an example of a disease that exists only because it has a name.
http://content.nejm.org/cgi/content/full/333/1/66
http://www.emedicine.com/med/topic1770.htm
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| epica
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From Goljan 
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| drduck
Forum Guru
Topics: 82
Posts: 529
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yes its in HL....
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