RayBerg
Forum Senior
Topics: 32
Posts: 150
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6. the clearance of several substances was measured at a constant
glomerular filtration rate and constant urine flow rate, but at
increasing plasma concentrations of the substance. Under these
conditions, clearance will increase at high plasma concentrations
for which of the following substances?
A. Creatinine
B. Mannitol
C. Penicillin
D. Phosphate
E. Urea
List in order of decreasing renal clearance the following substances:
glucose
urea
sodium
inulin
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| peraspera
Forum Elite
Topics: 38
Posts: 233
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creatinine
clearance of creat. is always slightly greater than clearance of inulin bs creatinine is filtered and small amount exhibits net secretion.
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| drduck
Forum Guru
Topics: 82
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Q 1........has to be creatinine....
Q 2........inulin>>>urea===sodium>>>glucose
hey urea and sodium equal.....plz tell me if i am wrong
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| RayBerg
Forum Senior
Topics: 32
Posts: 150
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Duck, I was under the impression that urea is greater than sodium..I'll have to check that again.
On Q1, you missed it (so did I), care to venture another guess? If not, I'll post the answer in 1 day. It is a VERY interesting q, so I want to give other posters time to get it right.
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| drduck
Forum Guru
Topics: 82
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is it penicillin????
just came to my mind that we give probenacid to decrease its secretion......so as to prolong its action.....and inhibit early elimination.....
i m waiting for ur answer
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| RayBerg
Forum Senior
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The only substances whose clearance increases with an increase in their plasma concentration alone, are those which are normally actively reabsorbed and have T max....say glucose.
Since most of the Phosphate that is filtered is reabsorbed only in the proximal tubule via cotransport, my answer would be Phosphate.
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| drduck
Forum Guru
Topics: 82
Posts: 529
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this one really made me think hard.....
i have to read......again
thnx rayberg.....that was nice Q
and do tell me if urea has more clearence than sodium...
what about sodium and potassium??? which has more...
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| venureddy82
Forum Newbie
Topics: 0
Posts: 3
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I THINK ITS PENICILLIN. PARA AMINO HIPPURIC ACID HAS INCREASED FILTRATION WITH INCREASING CONCENTRATION. THE SAME GOES WIT PENICILLIN TOO. I remember this q,its from kaplan physiology notes.
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| RayBerg
Forum Senior
Topics: 32
Posts: 150
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Venu, this question is from McGill website where the answer is Phosphate.
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| RayBerg
Forum Senior
Topics: 32
Posts: 150
|
Duck, unfortunately, I could not find the answer out for ya. In case you found it, do let me know. In this case, until someone else chimes in and gives a good explanation, I'll go w/ the answers to this question.
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