soumadoc
Forum Newbie
Topics: 9
Posts: 19
|
all nucleated cells have CMH 1 on their surface so that they can present endogenous peptides to CD8+ is that mean that all nucleated cells are antigen presentation cells?
|
| unique1
InGodITrust
Topics: 19
Posts: 1,405
|
All nucleated cells are not APCs. MHC1 has another role as well. This other role is to tell the phagocytes if a particular cell is self or non-self. MHC1 is like an ID card for the cells of your body and all the cells carrying this ID card are recognised by the body as self and not phagocytosed. If cells from another person , carrying a different ID card (MHC1 specific to that other person ) get entry into your body , they are recognized as strangers and killed.
___________________
I can't change the direction of the wind, but I can adjust my sails to always reach my destination.
|
| new_n_lost
Politically InCorrect
Topics: 654
Posts: 6,119
|
Someone has really studied Immunology very well !!!!
Nice Explanation, 
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
| unique1
InGodITrust
Topics: 19
Posts: 1,405
|
Thanks NnL 
Robbins buddy , Robbins !!!!!!  
___________________
I can't change the direction of the wind, but I can adjust my sails to always reach my destination.
|
| epica
|
MAJOR HISTOCOMPATIBILITY COMPLEX
All MHC molecules have antigen-binding sites that noncovalently bind short peptides produced by intracellular degradation of proteins. Recognition of MHC-associated peptides derived from foreign proteins triggers immune responses by T cells. CD8 cytolytic T cells recognize antigens associated with class I MHC molecules, which are expressed by all nucleated cells. CD4 helper T cells recognize antigens associated with class II MHC molecules, which are expressed by a limited number of cell types, collectively called antigen-presenting cells.
|
| epica
|
Which CYTOKINES SECRETED BY DENDRITIC CELLS AND MACROPHAGES?
|
| simi
Forum Elite
Topics: 53
Posts: 358
|
Dendritic cells secrete Inteleukin -1
Macrophages secrete ---------- IL-1,IL-6, IL-8, IL-12, Transforming growth factor-beta, tumor necrosis factor- alpha, granulocyte colony stimulating factor. granulocyte macrophage colony stimulating factor.
|
|
| |
| | | | | | | |
