new_n_lost
Politically InCorrect
Topics: 653
Posts: 6,085
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alright this i didnt know abt will have to search i guess.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| epica
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Growth Factor Receptors. Several oncogenes that encode growth factor receptors have been found. To understand how mutations affect the function of these receptors, it should be recalled that several growth factor receptors are transmembrane proteins with an external ligand-binding domain and a cytoplasmic tyrosine kinase domain In the normal forms of these receptors, the kinase is transiently activated by binding of the specific growth factors, followed rapidly by receptor dimerization and tyrosine phosphorylation of several substrates that are a part of the signaling cascade. The oncogenic versions of these receptors are associated with constitutive dimerization and activation without binding to the growth factor. Hence, the mutant receptors deliver continuous mitogenic signals to the cell.
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| new_n_lost
Politically InCorrect
Topics: 653
Posts: 6,085
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Thanks Buddy 
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| po
Forum Elite
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