asmi
Forum Hero
Topics: 1043
Posts: 4,609
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A 7-month-old child with failure to thrive is found to have a hemoglobin
of 4.4 g/dL. The peripheral smear shows very small red cells with marked
pallor. It is determined that the child has very low levels of
hemoglobin A, with elevated fractions of hemoglobin A2 and hemoglobin F.
Which of the following underlying mechanisms is most likely related to
the observed findings?
A. Amino acid substitution on b globin
B. Antibody against fetal blood cells
C. Cytoskeletal protein defect
D. Insufficient production of b globin
E. Iron deficiency
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| kiranmayi
Forum Guru
Topics: 237
Posts: 407
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it is D. Insufficient production of b globin
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| gr_calif
Forum Junior
Topics: 3
Posts: 51
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the patient is suffering from BETA THALASSEMIA due to INSUFFICIENT PRODUCTION OF b CHAINS.
elevated fractions of HBA2 containing 2ALPHA and 2 DELTA chains, and HBF containing 2ALPHA and 2 GAMMA chains is a compensatory measure.
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