whournameiz
Forum Senior
Topics: 40
Posts: 94
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Infection with plasmodium falciparum confirmed by peripheral smear.drug given which later on caused tinnitus, prolonged QT.what was the drug?
a hydroxychloroquine
b quinidine
c quinine,
d mefloquine.
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| peraspera
Forum Elite
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Intravenous quinidine is also indicated for treatment of P.falciparum malaria . Quinidine-induced trombocytopenia(low platelet count) is mediated by the immune system, and may lead to thrombocytic purpura . Quinidine intoxication can lead to a collection of symptoms collectively known as cinchonism with tinnitus (ringing in the ears) being among the most characteristic and common symptoms of this toxicity syndrome. The effect of quinidine on the ion channels is to prolong the cardiac action potential, thereby prolonging the QT interval on the surface EKG.
It can't be hydroxycloroquine bs it often used for treatment of autoimmune diseases.
I would go with quinidine ( with these symptoms of side effect.
What is right answer?
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| simi
Forum Elite
Topics: 53
Posts: 358
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B 
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| whournameiz
Forum Senior
Topics: 40
Posts: 94
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I don't know the right answer,  this is from step 1
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| jean robert
Forum Guru
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C
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| new_n_lost
Politically InCorrect
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c quinine
Quinidine in US is used under very severe falciparum malaria inf as an IV in Hospital Settings so therefore it has to be quinine cos the effects r same
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| drduck
Forum Guru
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dont know Quinidine given for falciparum or not.........
what i know......
quinine can cause symtoms like tinnitusand other mentioned in the Q.....
its still drug of choice for falciparum malaria....
still will see to it........
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| epica
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mefloquine.
Why not?
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| epica
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????
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| new_n_lost
Politically InCorrect
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Mefloquine though a synethetic analog of quinine more commonly causes Depression headaches and dizziness and bad dreams or hallcinations and seizures. though it does causes cardiac conduction defects but at very high dosages. ref Katzung
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| epica
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Mefloquine is the drug of choice in chloroquine-resistant regions
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| rishta
Forum Newbie
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Posts: 21
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ans is quinine.
side effects of mefloquine r nvd,dizziness,syncope,arrythmias and cns effects r rare..it doesnt cause "tinnitus"...correct if if im wrong
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