asmi
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Can anybody differentiate both ?
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| gr_calif
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MULTIPLE MYELOMA is due to clonal proliferation of neoplastic PLASMA CELLS in the bonemarrow associated with MULTIFOCAL LYTIC lesions throughout the skeleton system.
5TH AND 6TH decade of life.
:arrow: "M component is IgG."
MC presentation is BONE PAIN and PATHOLOGICAL FRACTURES,MC affected is the VERTEBRAL COLUMN.
other imp features are the" MYELOMA NEPHROSIS' :arrow: interstitial infiltrates of abnormal plasma cells and protenaceous casts made of bence jones proteins within the DCT and CT and HYPERCALCEMIA :arrow: metastatic calcification.
WALDERSTORMS MACROGLOBULINEMIA also involves the B cells that are sufficiently diff to produce immunoglobulins but not enough to look like plasma cells.
6TH AND 7TH decade of life.
:arrow: "M component is IgM '"
the neoplastic B cells diffusely infiltrate the LYMPHOID ORGANS including the bonemarrow,lymph nodes and spleen.
The macroglobulin forms large aggregates and increases the viscosity of blood :arrow: HYPERVISCOSITY SYNDROME with S/S of VISUAL IMPAIRMENT, NEUROLOGICAL PROBLEMS, BLEEDING ,CYROGLOBINEMIA.
one common feature anyway is both are progressive disesse with median survival of 2-4yrs.
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| asmi
Forum Hero
Topics: 1043
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thanks 
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| usmleasr
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thanks :roll:
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