whournameiz
Forum Senior
Topics: 38
Posts: 94
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Vignette of COPD with copious sputum. drug to be given?
Salmeterol,zafirlukast,ipratropium
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| keepgoing
Forum Guru
Topics: 62
Posts: 1,673
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ipratropium..
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| drduck
Forum Guru
Topics: 82
Posts: 529
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SALMETEROL........ will decrease airway resistance....also decrease narrowing of bronchus, will not decrease sputum production.
ZAFIRLUKAST........will have and anti inflamatory effect......will not decrease sputum production
IPRATOPIUM..........antichonergic..........acts on bronchial glands that are responsible for excessive sputum production...
none except....IPRATOP....acts on glands......
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| edie
I can, and I will.
Topics: 26
Posts: 1,235
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Zafirlukast!
Bronchodilator Effect of Zafirlukast in Subjects With Chronic Obstructive Pulmonary Disease
Nannini LJ, Flores DM
Pulm Pharmacol Ther. 2003;16:307-311
Cysteinyl leukotrienes (LT) are involved in airway inflammation and mucus
hypersecretion, characteristically present in asthma and COPD.
Zafirlukast is an LT receptor antagonist that improves airway function
within 1 to 3 hours after oral administration in subjects with chronic
persistent asthma...In conclusion, these findings suggest that zafirlukast has a
bronchodilator or antibronchoconstrictor effect in COPD patients with
severe airflow limitation.
For more: http://www.medscape.com/viewarticle/460154
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