asmi
Forum Hero
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What is the most common cause ?
What are the diagnostic features ?
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| gr_calif
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HUS most commonly follows gastroenteritis caused by E.coli 0157:H7 with onset in childhood.
endothelial cell injury is the primary event , leads to formation of myriads of PLATELET-FIBRIN HYALINE MICROTHROMBI that occludes arterioles and capillaries.This leads to consumtive THROMBOCYTOPENIA, MICROANGIOPATHIC HEMOLYTIC ANAEMIA . There is also FEVER and dominance of ACUTE RENAL FAILURE[kidney is pale and swollen, has a flea bitten appearance] .
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