macrophage of skin and brain

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Prep4USMLE Forum » USMLE Step 1 Forum » Histology & Molecular Biology

macrophage of skin and brain

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15 Posts

asmi
Forum Hero

Topics: 1043
Posts: 4,609

03/01/04 - 09:57 AM

What are the macrophages of skin ?
What is the macrophage of brain ?

peekay
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Posts: 588

03/01/04 - 11:12 AM

skin=histicytes
brain=astrocytes

asmi
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03/01/04 - 01:18 PM

correct

Ritalin
Forum Newbie

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07/09/04 - 06:51 PM

Nope.

Microglia work as the macrophage of the brain.

"Histiocyte" is a not very accurate name that regular, omnipresent macrophages have. Since you said skin, and did not specify what part of the skin you are talking about, saying that the macrophage of the skin is the macrophage (i.e. histiocyte) is correct. However, if you are talking about the antigen-presenting cell of the skin, the answer is Langerhans' cell (not related with the Langerhans' corpuscle of the pancreas).

meghana jadhav
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07/12/04 - 11:13 AM

agree with u ritalin

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megha

BumbleB
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08/04/04 - 08:28 PM

:P I agree microglia are brain macrophages, astrocytes are supporting cells.

BTW as a BONUS what disease are microglia responsible for introducing into the brain (there's more than one) but this one I'm thinking off is HUGE.

:wink: :?:

Ritalin
Forum Newbie

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08/05/04 - 03:28 PM

"BumbleB" wrote:
:P I agree microglia are brain macrophages, astrocytes are supporting cells.

BTW as a BONUS what disease are microglia responsible for introducing into the brain (there's more than one) but this one I'm thinking off is HUGE.

:wink: :?:

Huge? AIDS then. In general, AIDS virus is very fond of the cells of the monocyte-macrophage lineage. Dendritic cells and microglia are favourite targets, and microglia eagerly takes the virus from the blood into the brain.

BumbleB
Forum Junior

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Posts: 83

08/07/04 - 12:13 PM

exactly what i was thinking off...poor microglia. so eager to take the virus into the brain, and so clueless about its deadly consequences...

here's a silly bonus question: which mutation is associated with decreased HIV infection:

1.delta F 508
2.delta CCR5
3.delta CXCR4
4.-5p15

:wink:

mash
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08/07/04 - 12:18 PM

CCR5

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BumbleB
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Posts: 83

08/07/04 - 12:26 PM

#10

good answer - and fast too.

amitjosh
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Posts: 116

08/09/04 - 01:45 PM

#11

I thought CCR5 and CXCR4 both are correct answers

Amit Joshi

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Criticisms welcome

BumbleB
Forum Junior

Topics: 2
Posts: 83

08/09/04 - 07:01 PM

#12

Yeah they're both involved in HIV transmission but I've never heard of CXCR4 mutation, but CCR5's mutations are common (10% heterozygotes in some European populations).

h20
Forum Newbie

Topics: 6
Posts: 10

08/15/04 - 10:25 PM

#13

Hi,

I just studied this stuff yesterday, so to cap it, there are 5 total mutations discovered in the different presentaiton of patient w/HIV. CCR5 is definetly the most common, its fnx is to take the virus inside the cell, so mutated pt have almost undetectable viral load, second is cxcr4. recently the discovery is CXCR1 which has rapid infection/virus transmissibility than nl pt. exactly what MASH, amitjosh, and bumbleB said :o)

BumbleB
Forum Junior

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Posts: 83

08/16/04 - 04:05 PM

#14

Thanks for the info :P I can feel my brain growing... :shock: smiling face

mildus
Forum Guru

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Posts: 614

07/07/05 - 10:15 AM

#15

macrophage of brain are microglia

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