keepgoing
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Which of the following best describes the action of muscarinic cholinergic agonists?
A. Activate inhibitory G-proteins (Gi)
B. Decrease production of inositol triphosphate (IP3)
C. Decrease release of intracellular calcium
D. Inhibit the activity of phospholipase C
E. incraese extracellular calcium
too basic thing....
Edited by keepgoing on 05/28/07 - 10:34 AM
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| Addicudo
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E. incraese extracellular calcium too basic thing.. BUt i aint sure for this one ... answered by exclusion method ..
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| Addicudo
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Even A. Activate inhibitory G-proteins (Gi) if you talk about M2 Receptors ... 
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| me007
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choice E - extracellular Ca, what is not..
only A.
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| drduck
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E
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| new_n_lost
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E. incraese extracellular calcium
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| lq2006
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incraese extracellular calcium
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| keepgoing
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| keepgoing
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ans is A
In addition to activating inhibitory Gi, muscarinic cholinergic agonists stimulate the activity of phospholipase C, increase production of IP3 and increase release of intracellular calcium
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| jean robert
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In this case, A is definitely the answer. But not all the muscarinic receptors have the same mechanism.
M1 , M3 and M5 muscarinic receptors are coupled with G proteins of class Gq which upregulate phospholipase C and therefore inositol trisphosphate and INTRACELLULAR calcium as a signalling pathway.
M2 and M4 muscarinic receptors act via a Gi type receptor, which causes a decrease in cAMP in the cell, generally leading to inhibitory-type effects
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