Addicudo
Forum Guru
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34 group A given: chloramphenicol group B given: chloramphenicol and metronidazole to find out efficacy of chloramphenicol.then given vice versa.
Which study: cross overà case control,cohort,cross sectional
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| paheli
It'sAllAboutGoodKarma
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cross over
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| Addicudo
Forum Guru
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sure about it ... i never came across it .. 
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| paheli
It'sAllAboutGoodKarma
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Yep, cross over study is where the 2 groups are switched at some unknown point of the study so that both groups receive the treatment. It's a double blind study, and the crossing over is done for ethical reasons, as no group should be denied the treatment
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Prepare as if you're the worst, Perform as if you're the best! As you dream, so you manifest. So, DREAM BIG!! When you face hardship, remember, God never gives you more than you can handle. Keep your face to the sunshine and you cannot see the shadows.
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| epica
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Yes, cross over...(used often in research world)
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| rock
Forum Elite
Topics: 23
Posts: 305
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yup cross over study and paheli explained it well
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| epica
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Crossover study
From Wikipedia, the free encyclopedia
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A crossover trial also referred to as a crossover study is one where patients are given all of the medications to be studied, or one medication and a placebo in random order. These studies are generally done on patients with chronic diseases to control their symptoms. The data is analyzed according to the original intention to treat.
A crossover study has the advantage over a simple double-blind study that the variability between patients is minimized because each patient crossing over in effect serves as their own control. One disadvantage is that long term effects cannot be tracked with this approach. Another disadvantage is that curative therapies cannot be tested after one another or before a placebo for obvious reasons.
There are some important issues with respect to the design of cross-over studies. Two in particular may often crop up.
First is the issue of order effects, because it is possible that the order in which treatments are administered may affect the outcome. An example might be a drug with many adverse effects given first, making patients taking a second, less harmful medicine, more sensitive to any adverse effect.
Second is the issue of carry-over between treatments. In practice carry-over can be and is often dealt with by the use of a wash-out period between treatments, or by making observations sufficiently later after the start of a treatment period that any carry-over effect is minimized.
[edit] See also
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