tompat
Forum Elite
Topics: 39
Posts: 345
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hi all
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| new_n_lost
Forum Hero
Topics: 674
Posts: 6,150
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A
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| drduck
Forum Guru
Topics: 82
Posts: 523
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this one seems to be real bouncer.....
but i dont under stand...what is this C gene....
what i know for heavy chain its V,D,J....and for light chain its V and J.
what is this C then...
going thru the options i felt only option D makes some sense as it will give rise to formation of only heavy chain and no light chain....
as kappa and lamda are light chains for synthesis of both primary Igs....that is....IgM and IgD....
so there will be formation of light chain deficient Igs.....
new and lost seems to have different approach....plz discuss
and tompat plz post the answer and if possible the explaination...
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| tompat
Forum Elite
Topics: 39
Posts: 345
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ok ans is A.
C gene we are talking about is the gene encoding constant region of Ig. we need to have a clear idea of which chromosome encodes for which part of Ig.
genes for entire heavy chain are on chromosome 14( thic includes constant and variable region of heavy chain)
light chains--
kappa----- v(variable)---chromo 2
c(constant)---chromo 2
lambda----v(variable)--chromo 22
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| tompat
Forum Elite
Topics: 39
Posts: 345
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so the monosomy of chromo 14 will affect all Ig s, as it encodes for all the isotypes
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| drduck
Forum Guru
Topics: 82
Posts: 523
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fine....
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