new_n_lost
Politically InCorrect
Topics: 653
Posts: 6,070
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Alright this is getting out of hand
Now Listen to the Dunn Lectures n Esp the Part where he is discussing the Adrenal Cortex Malfunctions. Though He doesnt give the exact reasoning. but here it is
Zona Glomerulosa has DOC which converts it into Aldosterone.
Zona Fasiculata n Reticularis also have DOC normally which gets converted into 11-Deoxycortisol
the % age of Zona Glomerulosa in the Cortex is 15% and the rest is Fasiculata n Reticularis so in the 11-Hydroxylase Deficiency its the Fasiculata n Reticularis DOC is the one which causes the Major Damage cos the Quantity produced by it is very large which is exerting the effects of Weak Mineralocortiod.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| epica
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Your Q is
Don't be nervous, Lucky
What the mechanism of HTN in a pt with 11 hydroxylase deficiency enzyme ?
The ans ia D because only weak mineralocort can incr BP? (z. glomerul)
NNL, we did similar Q from the Physio Q bank. Remember?
How r U?
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| new_n_lost
Politically InCorrect
Topics: 653
Posts: 6,070
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To Luckyall
Sometimes Short hand can be misunderstood so when explaining plz give a little extra detail so that some ppl can understand 
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
Politically InCorrect
Topics: 653
Posts: 6,070
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Epica .............. i m fine
Yes i think we did but i cant seem to recall that one but apparently Dunn is right when he says its the DOC coming from Fasiculata n Reticularis which does the most damage cos the one Produced by Glomerulosa is not enuf to exert the Mineralocortoid effect.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| Luckyall
Forum Guru
Topics: 11
Posts: 593
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 thanks
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| epica
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Sure, Dunn is right.
Lucky is this ur Q ? Instead of "only" I think it should be "mostly" or something that
Pl, ans
Good point, guys
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| ssrpk
Forum Fanatic
Topics: 154
Posts: 2,809
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just to strike one more hammer to this topic.....
its all about negative feedback, in case of 11.beta hydroxylase def. its the zona-fasciculata and rerticularis which are effected but not the glomerulosa, as its negative feedback is based on Renin and angiotensinII, which wil be suppressed due to inadequately high secretion of weak mineralocorticoids from the unopposed zona fasciculata and reticularis.
so answer is C
good question lucky
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life is guud
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