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Kaplan Qbank USMLE



Author10 Posts
  #1

A 45 year old woman has an acute coronary occlusion. within seconds the ischemic region shows mitochondrial swelling and depletion of glycogen granules. which of the following metabolic events is most likely cause of these cellular changes?
A. accumulation of free faty acids
B. ATP depletion
C. degradation of membrane phosholipids
D.efflux of K
E influx of Na


  #2

B,
loss of ATP causes malfunction of Na-k pump which is ATP dependent, hence there is Na influx and cellular swelling as Na carries water along with it.

As far as depletion of glycogen is concerned, its due to increased metabolism of glycogen(via glycolysis) to provide ATP, which were earlier provided by ETC

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" No matter how steep the mountain is, God will climb it with you."

  #3

i think b

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لا اله الا الله محمد رسول الله

  #4

shaking head

  #5

i was even thinking this but the answer says C ....irreversible injury bcoz mitochondrial swelling

i dont get this can someone plz explain

  #6

c mmon guys

  #7

kingusmle wrote:
i was even thinking this but the answer says C ....irreversible injury bcoz mitochondrial swelling

i dont get this can someone plz explain

Dude u can not have answer to NBME

2ndly the Initial Effect of Hypoxia will induce ATP Depletion which will result in the initial swelling of mitochrondria n loss of glycogen granules and then u lose the NA/K ATPase pump leading to influx of H2O due to the presence of increased Na in the Cell. Degradation of Membrane Phospholipid is found in Irreversible Cell Injury till then the cell can be salvaged.


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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."

  #8

B it is ... !! ... within seconds the ischemic region shows mitochondrial swelling and depletion of glycogen granules Signs of Reversible injusry .. so def not C .. !!!

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... Idle hands are the DeVilS play ground ...

  #9

by saying answer is the ans i got from another usmle forum

  #10

WEll u can Choose whtever u seem is right to u

___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."







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