Jackofknives
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Protooncogenes produce products that have specific roles in regulating growth and differentiation of normal cells. Mutations can turn these genes into oncogenes whose products are less responsive to normal control. Unmutated protein p53, a tumor suppressor, is a transcription factor, inhibiting some genes and activating others. p53 inhibits genes with TATA sequences and activated genes for DNA repair.
The TATA sequence: 199
A) occurs about 25 bp downstream from the start of transcription
B) binds directly to RNA polymerase
C) binds transcription factors which bind RNA polymerase
D) binds p53
E) is an enhancer sequence
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| keepgoing
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c
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| SILVER
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e?
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| doc179
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C
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| Jackofknives
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Answer is C
B: RNA polymerase does not bind directly to TATA, but to transcription factors that bind TATA.
A, E: TATA is part of the promoter, so it is upstream from the transcription start.
D: p53 probably binds to the complex formed between transcription factors and TATA. Interfering with transcription.
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