me007
Forum Guru
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if someone could explain this 
resistance to cytosine arabinosid (araC) in some cases related to an increase in enzyme cytidine deaminase in the tumor cells.
This enzyme would inactivate araC to form
1. cytosine
2. cytidic acid
3. thymidine arabinoside
4. uracil arabinoside
5. cytidine.
Edited by me007 on 05/15/07 - 05:03 PM
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| jole
Forum Elite
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4
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| new_n_lost
Politically InCorrect
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4. "araC": cytosine arabinoside
This is a nucleoside analog with an altered sugar (arabinose) instead of ribose.
Cytidine deaminase will remove the amine group, converting this to innocuous uridine arabinoside. Cells that overproduce CD are protected against the anti-tumor avtivity of araC.
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| new_n_lost
Politically InCorrect
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This Diagram can help
Attached Files:
Cytdine Deaminase.doc (28 KB, 10 downloads)
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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